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Titolo:
Positive end-expiratory pressure preserves surfactant function in preterm lambs
Autore:
Michna, J; Jobe, AH; Ikegami, M;
Indirizzi:
Childrens Hosp, Med Ctr, Div Pulm Biol, Cincinnati, OH 45229 USA ChildrensHosp Cincinnati OH USA 45229 ulm Biol, Cincinnati, OH 45229 USA
Titolo Testata:
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
fascicolo: 2, volume: 160, anno: 1999,
pagine: 634 - 639
SICI:
1073-449X(199908)160:2<634:PEPPSF>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXOGENOUS SURFACTANT; LUNG-FUNCTION; VENTILATION STRATEGIES; TREATMENT RESPONSES; IN-VIVO; RABBITS; INJURY; PROTEINS; THERAPY; MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Ikegami, M Childrens Hosp, Med Ctr, Div Pulm Biol, 3333 Burnet Ave, Cincinnati, OH 45229 USA Childrens Hosp 3333 Burnet Ave Cincinnati OH USA 45229 5229 USA
Citazione:
J. Michna et al., "Positive end-expiratory pressure preserves surfactant function in preterm lambs", AM J R CRIT, 160(2), 1999, pp. 634-639

Abstract

Ventilation style influences lung injury and the amount of large-aggregatebiophysically active surfactant in adult lungs. We asked how positive end-expiratory pressures (PEEP) would influence clinical responses and surfactant pools in surfactant-treated preterm lambs ventilated for 7 h with tidal volumes (VT) Of 10 ml/kg. The 126-d gestation preterms were delivered and treated with 100 mg/kg recombinant human surfactant protein C (rSP-C) containing surfactant and ventilated with zero, 4, or 7 cm H2O of PEEP. A comparison group was treated with natural sheep surfactant and ventilated with zero PEEP. Physiologic measurements were similar for lambs treated with rSP-C surfactant and natural surfactant. PEEP 4 and 7 improved oxygenation and compliance relative to either group of lambs ventilated with PEEP zero. The maximal lung volumes measured at 40 cm H2O pressure after 7 h ventilation for the PEEP 4 and 7 groups were more than double those measured for either PEEP zero group. Alveolar surfactant pools were larger for the PEEP 7 group,and the large-aggregate fraction was increased for the PEEP 4 and 7 groups, resulting in large-aggregate pool sizes that were 3-fold higher for the PEEP 4 and 4-fold higher for the PEEP 7 groups relative to the PEEP zero group treated with rSP-C surfactant. All large-aggregate surfactants lowered minimal surface tensions of a captive bubble to less than 5 mN/m. In pretermsurfactant-treated lambs PEEP improved lung function and maintained more of an rSP-C surfactant in the biophysically active form.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 21:00:08