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Titolo:
Inhibition of trophoblast adhesion to endothelial cells by the sera of women with recurrent spontaneous abortions
Autore:
Bulla, R; de Guarrini, F; Pausa, M; Fischetti, F; Meroni, PL; De Seta, F; Guaschino, S; Tedesco, F;
Indirizzi:
Univ Trieste, Dept Physiol & Pathol, I-34127 Trieste, Italy Univ Trieste Trieste Italy I-34127 siol & Pathol, I-34127 Trieste, Italy Univ Trieste, Ist Clin Med, I-34127 Trieste, Italy Univ Trieste Trieste Italy I-34127 Ist Clin Med, I-34127 Trieste, Italy IRCSS Burlo Garofolo, Inst Obstet & Gynecol, Trieste, Italy IRCSS Burlo Garofolo Trieste Italy nst Obstet & Gynecol, Trieste, Italy Osped Maggiore, IRCCS, Dept Internal Med, Milan, Italy Osped Maggiore Milan Italy iore, IRCCS, Dept Internal Med, Milan, Italy
Titolo Testata:
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
fascicolo: 2, volume: 42, anno: 1999,
pagine: 116 - 123
SICI:
1046-7408(199908)42:2<116:IOTATE>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTIPHOSPHOLIPID ANTIBODY; ANTICARDIOLIPIN ANTIBODIES; HUMAN CYTOTROPHOBLASTS; ENDOVASCULAR INVASION; SUCCESSFUL PREGNANCY; THROMBOSIS; COMPLEMENT; INDUCTION; MOLECULES; PHENOTYPE;
Keywords:
antibodies; cell adhesion; endothelial cells; RSA; trophoblast;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Tedesco, F Univ Trieste, Dept Physiol & Pathol, Via Fleming 22, I-34127 Trieste, Italy Univ Trieste Via Fleming 22 Trieste Italy I-34127 ieste, Italy
Citazione:
R. Bulla et al., "Inhibition of trophoblast adhesion to endothelial cells by the sera of women with recurrent spontaneous abortions", AM J REPROD, 42(2), 1999, pp. 116-123

Abstract

PROBLEM: May anti-phospholipid or other autoantibodies interfere with trophoblast-endothelial cells interaction in women with unexplained pregnancy losses? METHODS OF STUDY: The sera of 72 women with recurrent spontaneous abortions (RSA) containing antibodies to endothelial cells (28), trophoblast (14), and cardiolipin (10) or lacking antibodies (25). and 26 controls were examined in an inhibition assay of trophoblast adhesion to endothelial cells using an ELISA based un thr recognition of trophoblast by antibodies to cytokeratin. RESULTS: Adhesion of trophoblast to endothelial cells was time- and dose-dependent. Patients and control sera inhibited trophoblast adhesion with mean values of 37% and 7%, respectively. Inhibition above 2SD of the mean control value was still observed in 58% of the patients sera and 8% of the control sera. Sera containing antibodies to endothelial cells had higher inhibitory effect (38%) than those with antibodies to trophoblast (23%) and cardiolipin (28%) or lacking antibodies (26%). CONCLUSIONS: Antibodies and other undefined factors in the sera of women with RSA inhibit adhesion of trophoblast to endothelial cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 14:25:26