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Titolo:
Infection of human respiratory submucosal glands with rhinovirus: effects on cytokine and ICAM-1 production
Autore:
Yamaya, M; Sekizawa, K; Suzuki, T; Yamada, N; Furukawa, M; Ishizuka, S; Nakayama, K; Terajima, M; Numazaki, Y; Sasaki, H;
Indirizzi:
Tohoku Univ, Sch Med, Dept Geriatr Med, Aoba Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ, Sch Med, Dept Otorhinolaryngol, Aoba Ku, Sendai, Miyagi 9808574, Japan Tohoku Univ Sendai Miyagi Japan 9808574 Ku, Sendai, Miyagi 9808574, Japan Sendai Natl Hosp, Div Clin Res, Sendai, Miyagi 9800045, Japan Sendai Natl Hosp Sendai Miyagi Japan 9800045 endai, Miyagi 9800045, Japan
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
fascicolo: 2, volume: 21, anno: 1999,
pagine: L362 - L371
SICI:
1040-0605(199908)21:2<L362:IOHRSG>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERCELLULAR-ADHESION MOLECULE-1; EPITHELIAL-CELL LINE; SYNCYTIAL VIRUS; NASAL EPITHELIUM; NEUTROPHIL; EXPRESSION; CHILDREN; RECEPTOR; COLDS; INTERLEUKIN-8;
Keywords:
intercellular adhesion molecule-1; asthma; common cold; airway inflammation; interleukin-1; polymerase chain reaction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
37
Recensione:
Indirizzi per estratti:
Indirizzo: Sasaki, H Tohoku Univ, Sch Med, Dept Geriatr Med, Aoba Ku, Seiryo Machi 1-1, Sendai,Miyagi 9808574, Japan Tohoku Univ Seiryo Machi 1-1 Sendai Miyagi Japan 9808574 , Japan
Citazione:
M. Yamaya et al., "Infection of human respiratory submucosal glands with rhinovirus: effects on cytokine and ICAM-1 production", AM J P-LUNG, 21(2), 1999, pp. L362-L371

Abstract

To further understand the early biochemical events that occur in infected surface epithelium, we developed for the first time a model in which a respiratory submucosal gland cell population can be infected with rhinovirus (RV). Viral infection was confirmed by demonstrating with PCR that viral titers in supernatants and lysates from infected cells increased with time. Infection by RV14 upregulated the expression of intercellular adhesion molecule-1 (ICAM-1) mRNA the major RV receptor, on submucosal gland cells, and it increased production of interleukin (IL)-1 alpha, IL-1 beta, IL-6, IL-8, tumor necrosis factor-alpha, and granulocyte-macrophage colony-stimulating factor in supernatants. Antibodies to ICAM-1 inhibited RV infection of submucosal gland cells and decreased the production of cytokines after RV infection. Both IL-1 alpha and IL-1 beta upregulated ICAM-1 mRNA expression and increased susceptibility to RV infection, whereas other cytokines failed to alter ICAM-1 mRNA expression. Furthermore, neutralizing antibodies to IL-1 alpha and IL-1 beta significantly decreased the viral titers in supernatantsand ICAM-1 mRNA expression after RV infection, but a neutralizing antibodyto tumor necrosis factor-alpha was without effect. These findings suggest that respiratory submucosal gland cells play an important role in the initial stages of inflammation and provide useful insights into the pathogenesisof RV infection.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 17:54:03