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Titolo:
Molecular genetic aspects of oligodendrogliomas including analysis by comparative genomic hybridization
Autore:
Bigner, SH; Matthews, MR; Rasheed, BKA; Wiltshire, RN; Friedman, HS; Friedman, AH; Stenzel, TT; Dawes, DM; McLendon, RE; Bigner, DD;
Indirizzi:
Duke Univ, Med Ctr, Dept Pathol, Durham, NC 27710 USA Duke Univ Durham NCUSA 27710 Med Ctr, Dept Pathol, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Pediat, Durham, NC 27710 USA Duke Univ Durham NCUSA 27710 Med Ctr, Dept Pediat, Durham, NC 27710 USA Duke Univ, Med Ctr, Dept Surg, Durham, NC 27710 USA Duke Univ Durham NC USA 27710 v, Med Ctr, Dept Surg, Durham, NC 27710 USA
Titolo Testata:
AMERICAN JOURNAL OF PATHOLOGY
fascicolo: 2, volume: 155, anno: 1999,
pagine: 375 - 386
SICI:
0002-9440(199908)155:2<375:MGAOOI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN GLIOMAS; TUMORS; PROGRESSION; CHROMOSOME-19; MUTATIONS; DELETION; 1P;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Bigner, SH Duke Univ, Med Ctr, Dept Pathol, Box 3712, Durham, NC 27710 USADuke Univ Box 3712 Durham NC USA 27710 12, Durham, NC 27710 USA
Citazione:
S.H. Bigner et al., "Molecular genetic aspects of oligodendrogliomas including analysis by comparative genomic hybridization", AM J PATH, 155(2), 1999, pp. 375-386

Abstract

Oligodendroglial neoplasms are a subgroup of gliomas with distinctive morphological characteristics. In the present study we have evaluated a series of these tumors to define their molecular profiles and to determine whetherthere is a relationship between molecular genetic parameters and histological pattern in this tumor type. Loss of heterozygosity (LOH) for 1p and 19qwas seen in 17/23 (74%) well-differentiated oligodendrogliomas, in. 18/23 (83%) anaplastic oligodendrogliomas, and in 3/8 (38%) oligoastrocytomas grades II and III. LOH for 17p and/or mutations of the TP53 gene occurred in 14 of these 55 tumors. Only one of the 14 cases with 17p LOH/TP53 gene mutation also had LOH for Ip and 19q, and significant astrocytic elements mere seen histologically in the majority of these 14 tumors. LOH for 9p and/or deletion of the CDKN2A gene occurred in 15 of these 55 tumors, and 11 of these cases were among the 24 (42%) anaplastic oligodendrogliomas. Comparative genomic hybridization (CGH) identified the majority of cases with Ip and 19q loss and, in addition, showed frequent loss of chromosomes ri, 14, 15, and 18. These findings demonstrate that oligodendroglial neoplasms usually have loss of Ip and 19q whereas astrocytomas of the progressive type frequently contain mutations of the TP53 gene, and that 9p loss and CDKN2A deletions are associated with progression from well-differentiated to anaplastic oligodendrogliomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/10/20 alle ore 02:14:37