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Titolo:
Measured-to-predicted creatinine generation ratio increases with time and decline in residual renal function in continuous ambulatory peritoneal dialysis
Autore:
Szeto, CC; Lai, KN; Wong, TYH; Law, MC; Li, PKT;
Indirizzi:
Chinese Univ Hong Kong, Prince Wales Hosp, Dept Therapeut, Hong Kong, Peoples R China Chinese Univ Hong Kong Hong Kong Peoples R China Kong, Peoples R China
Titolo Testata:
AMERICAN JOURNAL OF KIDNEY DISEASES
fascicolo: 2, volume: 34, anno: 1999,
pagine: 235 - 241
SICI:
0272-6386(199908)34:2<235:MCGRIW>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CROSS-SECTIONAL ASSESSMENT; CAPD PATIENTS; WEEKLY UREA; NONCOMPLIANCE; EXCRETION; PRESCRIPTION; CLEARANCES; INDEX;
Keywords:
compliance; creatinine generation; peritoneal dialysis; renal failure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
24
Recensione:
Indirizzi per estratti:
Indirizzo: Li, PKT Chinese Univ Hong Kong, Prince Wales Hosp, Dept Med, Hong Kong, Peoples R China Chinese Univ Hong Kong Hong Kong Peoples R China eoples R China
Citazione:
C.C. Szeto et al., "Measured-to-predicted creatinine generation ratio increases with time and decline in residual renal function in continuous ambulatory peritoneal dialysis", AM J KIDNEY, 34(2), 1999, pp. 235-241

Abstract

The expression of measured-to-predicted creatinine generation ratio (MIP) has been proposed as an index of compliance in continuous ambulatory peritoneal dialysis (CAPD) patients. Although M/P may not be sensitive enough forcross-sectional study, serial monitoring has been suggested to identify noncompliance. We attempted to evaluate serial changes of M/P from a nonselected group of CAPD patients, Sixty-three patients, all followed up for 2 years, were reviewed retrospectively. Their MIP ratios at years 0 and 2 were computed and compared, Baseline MIP had a normal distribution with a mean of0.96 +/- 0.26. There was significant correlation between baseline MIP and residual glomerular filtration rate (GFR; r = -0.81; P < 0.0001). There were weak correlations between M/P and duration of dialysis (r = 0.52; P < 0.0001), body weight (r = -0.52; P < 0.0001), KW (r = 0.31; P < 0.02), weekly creatinine clearance normalized to body surface area (r = 0.53; P < 0.0001), and serum albumin level (r = -0.28; P < 0.05), After 2 years, M/P increased in 56 of 63 patients (88.9%). Average M/P increased from 0.96 +/- 0.26 to 1.31 +/- 0.27 (P < 0.0001). Multivariant analysis showed MIP at year 0, which was largely determined by residual GFR, was the only independent factor affecting increase in M/P from year 0 to year 2. The general trend of increasing M/P was still present when only anuric patients were analyzed, although that was not statistically significant (1.21 +/- 0.14 to 1.32 +/- 0.24; P = 0.12). The finding of increasing M/P with time in CARD patients, particularly those with significant residual renal function, suggests MIP may not be a reliable indicator of noncompliance, even for serial follow-up of the same patient. Better methods for assessment of compliance in CAPD patients are required. (C) 1999 by the National Kidney Foundation, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 11:58:50