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Titolo:
Urinary oxalate and urate to creatinine ratios in a healthy pediatric population
Autore:
Matos, V; Van Melle, G; Werner, D; Bardy, D; Guignard, JP;
Indirizzi:
CHU Vaudois, Nephrol Unit, Serv Pediat, Dept Pediat, CH-1011 Lausanne, Switzerland CHU Vaudois Lausanne Switzerland CH-1011 , CH-1011 Lausanne, Switzerland Univ Lausanne, Inst Social & Prevent Med, CH-1015 Lausanne, Switzerland Univ Lausanne Lausanne Switzerland CH-1015 CH-1015 Lausanne, Switzerland CHUV, Cent Lab Clin Chem, Lausanne, Switzerland CHUV Lausanne Switzerland UV, Cent Lab Clin Chem, Lausanne, Switzerland
Titolo Testata:
AMERICAN JOURNAL OF KIDNEY DISEASES
fascicolo: 2, volume: 34, anno: 1999,
pagine: 1 - 6
SICI:
0272-6386(199908)34:2<1:UOAUTC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
URIC-ACID EXCRETION; GLYCOLATE EXCRETION; CHILDREN; CALCIUM;
Keywords:
infants; children; adolescents; reference values; percentiles; urinary oxalate excretion; urinary urate excretion; solute excretion; urine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Guignard, JP CHU Vaudois, Nephrol Unit, Serv Pediat, Dept Pediat, CH-1011 Lausanne, Switzerland CHU Vaudois Lausanne Switzerland CH-1011 sanne, Switzerland
Citazione:
V. Matos et al., "Urinary oxalate and urate to creatinine ratios in a healthy pediatric population", AM J KIDNEY, 34(2), 1999, pp. 1-6

Abstract

The purpose of the study was to determine reference percentiles for the urinary(U) oxalate (Ox) and urate (Ura) to creatinine (Cr) concentration ratios in the second morning urine of healthy infants, children, and adolescents. The urinary oxalate and urate to creatinine ratios were determined in the spontaneously voided second morning urine sample. To test reproducibility, two urine samples were analyzed on 2 consecutive weeks in 63% of the subjects. Three hundred eighty-four healthy children (181 girls, 203 boys), aged 1 month to 17 years, from nurseries, kindergartens, and schools of Lausanne, Switzerland, were studied. The 5th and 95th percentiles were determinedfrom the total number of urine samples (627) after confirmation that therewas no order effect between repeated measurements and there were no significant sex differences. A nonlinear regression analysis in terms of age was used to smooth the calculated percentiles. In this manner, curves were obtained from which the reference values can be read at any given age. The 95thpercentiles decreased with age: for UOx/Cr from 0.175 mg/mg (0.22 mol/mol)at 1 to 6 months to 0.048 mg/mg (0.06 mol/mol) from 7 years and beyond; and UUra/Cr from 2.378 mg/mg (1.6 mol/mol) at 1 to 6 months to 0.594 mg/mg (0.4 mol/mol) in adolescence. We provide 5th and 95th percentile curves for the UOx/Cr and UUra/Cr ratios determined from the second morning urine samples in a large cohort of healthy infants, children. and adolescents. Values were determined by standard analytical chemical techniques and were analyzed by powerful statistical methods. The calculated 95th percentile for the UOx/Cr values fell rather rapidly and reached normal adult values by the ageof 7 years, whereas for UUra/Cr, the 95th percentile decreased slowly and stabilized in adolescence. (C) 1999 by the National Kidney Foundation, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 23:56:32