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Titolo:
Intermittent milrinone effect on long-term hemodynamic profile in patientswith severe congestive heart failure
Autore:
Hatzizacharias, A; Makris, T; Krespi, P; Triposkiadis, F; Voyatzi, P; Dalianis, N; Kyriakidis, M;
Indirizzi:
Univ Athens, Sch Med, LAIKON Gen Hosp, Dept Cardiol, GR-10679 Athens, Greece Univ Athens Athens Greece GR-10679 Dept Cardiol, GR-10679 Athens, Greece
Titolo Testata:
AMERICAN HEART JOURNAL
fascicolo: 2, volume: 138, anno: 1999,
parte:, 1
pagine: 241 - 246
SICI:
0002-8703(199908)138:2<241:IMEOLH>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTRAVENOUS MILRINONE; MULTICENTER; INFUSIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Hatzizacharias, A 46 Panagiotara St, Athens 11475, Greece 46 Panagiotara St Athens Greece 11475 ns 11475, Greece
Citazione:
A. Hatzizacharias et al., "Intermittent milrinone effect on long-term hemodynamic profile in patientswith severe congestive heart failure", AM HEART J, 138(2), 1999, pp. 241-246

Abstract

Background Many reports have suggested that intermittent milrinone infusion (IMI) may be efficacious in the management of end-stage congestive heart failure (CHF), but this issue has not been clearly established. The aim of our study was to investigate the effectiveness of IMI in hospitalized patients with severe CHF undergoing long-term (4 months) post-therapy hemodynamics. Methods Thirty-six patients (28 men, 8 women; mean age 65.6 +/- 8.2 years old) with end-stage CHF (New York Heart Association functional class Ill-IV) were studied. Each patient received 4 cycles of 3 days per week with milrinone therapy. Each cycle consisted of a loading dose of 50 mu g/kg over 10minutes and a 72-hour continuous infusion of 0.5 mu g/kg per minute under close monitoring. Hemodynamic changes were determined during the first and fourth cycles and on 4-month reexamination. Full clinical examination was performed at the beginning (baseline) and at the end of 4-month follow-up. Results The values of mean pulmonary arterial pressure, pulmonary capillary wedge pressure, systemic vascular resistance, and pulmonary vascular resistance were significantly decreased (P <.01) and cardiac index was significantly increased (P < .01) compared with the baseline of first and fourth cycles. At the end of the 4-month follow-up period all hemodynamic parameterssustained the improvement. Clinical examination at the end of the 4-month period showed that 21 (58.3%) of 36 patients remained in New York Heart Association functional class IV but were hemodynamically improved, 13 (36.2%) of 36 were in functional class III, and 2 (5.5%) of 36 were in class II-III. There were no deaths during the study period. Conclusions Our findings suggest that IMI in hospitalized patients with severe CHF is hemodynamically efficacious. This beneficial hemodynamic effectis maintained for at least 4 months after discontinuation of therapy. These promising results raised the possibility that given appropriately, milrinone may have an important role in end-stage CHF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 15:34:02