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Titolo:
Sensitization to allergens of house-dust mite in adults with atopic dermatitis in a cold temperate region
Autore:
Holm, L; van Hage-Hamsten, M; Ohman, S; Scheynius, A;
Indirizzi:
Karolinska Inst, Stockholm Soder Hosp, Dept Dermatol, Stockholm, Sweden Karolinska Inst Stockholm Sweden Hosp, Dept Dermatol, Stockholm, Sweden Karolinska Hosp & Inst, Dept Lab Med, Div Clin Immunol, Stockholm, Sweden Karolinska Hosp & Inst Stockholm Sweden Clin Immunol, Stockholm, Sweden
Titolo Testata:
ALLERGY
fascicolo: 7, volume: 54, anno: 1999,
pagine: 708 - 715
SICI:
0105-4538(199907)54:7<708:STAOHM>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN LANGERHANS CELLS; PATCH TEST REACTIONS; INHALANT ALLERGENS; IN-SITU; IGE; CHILDREN; STANDARDIZATION; RECEPTOR; ASTHMA; SKIN;
Keywords:
atopic dermatitis; atopy patch test; house-dust-mite exposure; house-dust-mite sensitization; Stockholm region;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Holm, L Sophiahemmet Hosp, Dept Dermatol, Box 5605, S-11486 Stockholm, Sweden Sophiahemmet Hosp Box 5605 Stockholm Sweden S-11486 kholm, Sweden
Citazione:
L. Holm et al., "Sensitization to allergens of house-dust mite in adults with atopic dermatitis in a cold temperate region", ALLERGY, 54(7), 1999, pp. 708-715

Abstract

Background: An IgE-mediated contact reaction to airborne allergens has been suggested as one important pathogenetic mechanism in atopic dermatitis (AD). The house-dust mite (HDM) might be a common allergen involved. In Scandinavia, sensitization to HDM has been rare, probably because of the cold, dry climate. However, recent studies indicate high levels of domestic mites and HDM allergen in 15-20% of homes in central and northern Sweden. Methods: To evaluate the importance of the HDM in patients with AD in the Stockholm region, we screened 81 adult Stockholm residents with AD, for theprevalence and degree of sensitization to the HDM, according to specific IgE (RAST), skin prick test (SPT), and atopy patch test (Am). We also assessed the HDM exposure in their homes and correlated the results with clinicalhistory, severity of the dermatitis, and type of residence during childhood and today. Results: The sensitization rate to HDM was high (56% according to RAST, 24% according to SPT, and 47% according to APT), and 20% of the patients wereexposed to HDM allergens in their beds. Mite exposure seemed to aggravate the dermatitis in highly sensitized patients. Conclusions: The results indicate that we have to take the HDM into account when discussing aggravating factors in adult patients with AD in the Stockholm region.

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Documento generato il 20/09/20 alle ore 02:17:50