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Titolo:
Comparison of effects of surfactant and inhaled nitric oxide in rabbits with surfactant-depleted respiratory failure
Autore:
Zhou, BH; Sun, B; Zhou, ZH; Zhu, LW; Fan, SZ; Lindwall, R;
Indirizzi:
Shanghai Med Univ, Dept Pediat, Shanghai 200032, Peoples R China Shanghai Med Univ Shanghai Peoples R China 200032 00032, Peoples R China Shanghai Med Univ, Childrens Hosp, Res Inst, Shanghai 200032, Peoples R China Shanghai Med Univ Shanghai Peoples R China 200032 00032, Peoples R China Karolinska Inst, Danderyd Hosp, Dept Anaesthesiol & Intens Care, Danderyd 18288, Sweden Karolinska Inst Danderyd Sweden 18288 ntens Care, Danderyd 18288, Sweden
Titolo Testata:
ACTA PHARMACOLOGICA SINICA
fascicolo: 8, volume: 20, anno: 1999,
pagine: 691 - 695
SICI:
0253-9756(199908)20:8<691:COEOSA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISTRESS SYNDROME; EXOGENOUS SURFACTANT; THERAPY; OXYGENATION; CHILDREN; RATS;
Keywords:
adult respiratory distress syndrome; lung compliance; nitric oxide; phosphatidylcholines; pulmonary surfactants; respiratory therapy; bronchoalveolar lavage; anoxia; respiratory insufficiency; phospholipids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Sun, B Shanghai Med Univ, Dept Pediat, Shanghai 200032, Peoples R China Shanghai Med Univ Shanghai Peoples R China 200032 Peoples R China
Citazione:
B.H. Zhou et al., "Comparison of effects of surfactant and inhaled nitric oxide in rabbits with surfactant-depleted respiratory failure", ACT PHAR SI, 20(8), 1999, pp. 691-695

Abstract

AIM: To compare effects of pulmonary surfactant and inhaled nitric oxide (iNO) in improvement of survival and blood oxygenation in ventilated rabbitswith acute hypoxic respiratory failure induced by repeated bronchoalveolarlavage (BAL). METHODS: After BAL all the rabbits had more than 50 % reduction of dynamic lung compliance (C-dyn), 50 % increment of resistance of respiratory system (R-rs), and an increase of mean oxygenation index (OI) from1 to 22. The rabbits were then randomly allocated to groups receiving (1) mechanical ventilation only (Control), (2) iNO 0.8 mu mol . L-1(20 ppm) (NO), (3) intratracheal bolus surfactant phospholipids at 100 mg . kg(-1)(Surf), and (4) combined surfactant at 100 mg kg(-1) with inhaled NO at 0.8 mu mol . L-1(Surf + NO). All the rabbits were ventilated with standardized tidal volume (8 - 10 mL . kg(-1)) for another 8 h or until early death. RESULTS: The rabbits in both control and NO groups had the lowest survival rate, deterioration of lung mechanics and OI, whereas those in the Surf and Surf NO groups had modestly improved C-dyn, R-rs, and OI. Only rabbits in the Surf + NO group had significantly improved survival rate and alveolar expansion. CONCLUSION: Surfactant with or without NO is more effective compared to the control and iNO groups in rabbit, suggesting that iNO is not effective unless a method to reemit alveoli is applied.

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Documento generato il 29/03/20 alle ore 11:13:45