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Titolo:
Familial gastric cancer in the Japanese population is frequently located at the cardiac region
Autore:
Kakiuchi, H; Itoh, F; Kusano, M; Adachi, Y; Mita, H; Mihara, M; Matsuno, K; Endo, T; Hinoda, Y; Hosokawa, M; Imai, K;
Indirizzi:
Sapporo Med Univ, Sch Med, Dept Internal Med 1, Chuo Ku, Sapporo, Hokkaido060, Japan Sapporo Med Univ Sapporo Hokkaido Japan 060 , Sapporo, Hokkaido060, Japan Keiyukai Sapporo Hosp, Sapporo, Hokkaido, Japan Keiyukai Sapporo Hosp Sapporo Hokkaido Japan p, Sapporo, Hokkaido, Japan
Titolo Testata:
TUMOR BIOLOGY
fascicolo: 5, volume: 20, anno: 1999,
pagine: 235 - 241
SICI:
1010-4283(199909/10)20:5<235:FGCITJ>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONPOLYPOSIS COLON-CANCER; HELICOBACTER-PYLORI INFECTION; COLORECTAL-CANCER; RET PROTOONCOGENE; HIGH-RISK; MUTATIONS; GENE; HOMOLOG; CARCINOMA; DIET;
Keywords:
familiar gastric cancer; tumor location; histology; peritoneal dissemination; liver metastasis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Kakiuchi, H Sapporo Med Univ, Sch Med, Dept Internal Med 1, Chuo Ku, S-1,W-16, Sapporo, Hokkaido 060, Japan Sapporo Med Univ S-1,W-16 Sapporo Hokkaido Japan 060 60, Japan
Citazione:
H. Kakiuchi et al., "Familial gastric cancer in the Japanese population is frequently located at the cardiac region", TUMOR BIOL, 20(5), 1999, pp. 235-241

Abstract

The clinical features of familial gastric cancer are still unknown. To approach this question, we investigated the clinicopathological characteristics of 16 cases of familial gastric cancer. In this study the criteria used to define familiar gastric cancer was the existence of three or more family members with gastric cancer in at least two successive generations. The clinicopathological characteristics of cases who fulfilled this criteria were studied. This study contained 16 familial gastric cancer probands. Seven cases (44%) of gastric cancer had developed at the cardiac region of the stomach. This frequency was significantly higher than for gastric cancer in thegeneral population in Japan (15.4%, p < 0.01). Undifferentiated types weredominant in familiar gastric cancer (69%, p < 0.05). Furthermore, the frequency of disseminated peritoneal (40%) and liver metastases (20%) in familiar gastric cancer was also significantly higher than for gastric cancer in the general population in Japan (10.9%, p < 0.01, and 4.4%, p < 0.05, respectively). Familial gastric cancers were frequently located at the cardiac region and appeared to be more aggressive than sporadic gastric cancers. Theunique characteristics of familiar gastric cancer suggest a genetic background in their etiology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 18:42:27