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Titolo:
Sensitivity of neurons in somatosensory cortex (S1) to cutaneous stimulation of the hindlimb immediately following a sciatic nerve crush
Autore:
Barbay, S; Peden, EK; Falchook, G; Nudo, RJ;
Indirizzi:
Univ Kansas, Med Ctr, Dept Mol & Integrat Physiol, Kansas City, KS 66160 USA Univ Kansas Kansas City KS USA 66160 t Physiol, Kansas City, KS 66160 USA Univ Kansas, Med Ctr, Ctr Aging, Kansas City, KS 66160 USA Univ Kansas Kansas City KS USA 66160 Ctr Aging, Kansas City, KS 66160 USA Univ Texas, Hlth Sci Ctr, Dept Surg, Houston, TX 77030 USA Univ Texas Houston TX USA 77030 Sci Ctr, Dept Surg, Houston, TX 77030 USA Louisiana State Univ, Med Ctr, Sch Med, New Orleans, LA 70112 USA Louisiana State Univ New Orleans LA USA 70112 , New Orleans, LA 70112 USA
Titolo Testata:
SOMATOSENSORY AND MOTOR RESEARCH
fascicolo: 2, volume: 16, anno: 1999,
pagine: 103 - 114
SICI:
0899-0220(1999)16:2<103:SONISC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTIVE-FIELD ALTERATIONS; SOMATIC SENSORY CORTEX; CAT AUDITORY-CORTEX; ADULT FLYING-FOX; DIGIT DENERVATION; VISUAL-CORTEX; SI CORTEX; MACAQUE MONKEYS; CEREBRAL-CORTEX; STRIATE CORTEX;
Keywords:
cortical plasticity; cutaneous thresholds; somatosensory cortex; receptive field reorganization; peripheral nerve injury; silent synapses;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Barbay, S Univ Kansas, Med Ctr, Dept Mol & Integrat Physiol, 3901 Rainbow Blvd, Kansas City, KS 66160 USA Univ Kansas 3901 Rainbow Blvd Kansas City KS USA 66160 66160 USA
Citazione:
S. Barbay et al., "Sensitivity of neurons in somatosensory cortex (S1) to cutaneous stimulation of the hindlimb immediately following a sciatic nerve crush", SOMAT MOT R, 16(2), 1999, pp. 103-114

Abstract

While a large number of studies have examined receptive field alterations in the cerebral cortex after peripheral nerve injury, descriptions of neuronal sensitivity have been largely qualitative. In the present study, quantitative changes in minimal force thresholds evoking cortical responses were examined in somatosensory cortex (S1) of the rat after peripheral nerve injury. Cutaneous receptive fields were defined by conventional multi-unit recording techniques. Thresholds for evoking cortical responses were defined using Semmes-Weinstein monofilaments to stimulate the skin over the distal and proximal hindlimb, and over the adjacent tail, lower back and abdomen. Then minimal force thresholds and representational areas were compared. Receptive fields were recorded before and within 3 h after a sciatic nerve crush injury. Group comparisons were also made with intact (control) rats in which more detailed maps were derived. The results show that the minimal force thresholds for activation of newly emerged responses were not statistically different from thresholds for evoking pre-crush responses. These quantitative data provide strong support for the notion that functional boundariesin S1 between saphenous and sciatic representations and between distal andproximal hindlimb representations are actively maintained by selective inhibition of subsets of overlapping inputs. Formerly inhibited responses can be activated by low-threshold cutaneous stimulation immediately following peripheral nerve injury.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 20:59:55