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Titolo:
THYMOPENTIN TREATMENT OF RHEUMATOID-ARTHRITIS
Autore:
SUNDAL E; BERTELLETTI D;
Indirizzi:
CILAG SPA,VIA MICHELANGELO BUONARROTI 23 I-20093 COLOGNO MONZESE ITALY CILAG SPA I-20093 COLOGNO MONZESE ITALY
Titolo Testata:
Arzneimittel-Forschung
fascicolo: 10, volume: 44-2, anno: 1994,
pagine: 1145 - 1149
SICI:
0004-4172(1994)44-2:10<1145:TTOR>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL-BLOOD LYMPHOCYTES; SYNOVIAL-FLUID LYMPHOCYTES; THYMOPOIETIN PENTAPEPTIDE; GAMMA-INTERFERON; ACTIVATING FACTOR; HUMAN MONOCYTES; CELLS; TP-5; INTERLEUKIN-2; INVITRO;
Keywords:
HORMONES, THYMIC; IMMUNODEFICIENCIES; IMMUNOTHERAPY; RHEUMATOID ARTHRITIS; THYMOPENTIN, CLINICAL STUDIES, IMMUNOREGULATORY ACTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
E. Sundal e D. Bertelletti, "THYMOPENTIN TREATMENT OF RHEUMATOID-ARTHRITIS", Arzneimittel-Forschung, 44-2(10), 1994, pp. 1145-1149

Abstract

Although the etiology of rheumatoid arthritis (RA) is unknown, there is solid evidence that immunological factors play a pivotal role in its pathogenesis. It seems that a hyporeactivity of local (intraarticular) T-suppressor cells would permit an excessive immune response that ultimately leads to the classical symptoms and signs of inflammation and cartilage damage. Thymopentin is a synthetic pentapeptide (Arg-Lys-Asp-Val-Tyr) which represents the active biologic site (sequence 32-36)of the native thymic hormone thymopoietin, containing 49 amino acids. Thymopoietin and thymopentin have been shown to possess immuno-normalizing properties in a number of animal model systems. Low concentrations of the hormone characteristically stimulate the OKT4-positive cells, whereas higher concentrations additionally induce stimulation of OKT8-positive cells. This report summarizes the clinical experience collected by Italian investigators, and discusses the results with a view to previously published papers.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 02:59:18