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Titolo:
Complexity of terminal airspace geometry assessed by lung computed tomography in normal subjects and patients with chronic obstructive pulmonary disease
Autore:
Mishima, M; Hirai, T; Itoh, H; Nakano, Y; Sakai, H; Muro, S; Nishimura, K; Oku, Y; Chin, K; Ohi, M; Nakamura, T; Bates, JHT; Alencar, AM; Suki, B;
Indirizzi:
Boston Univ, Dept Biomed Engn, Boston, MA 02215 USA Boston Univ Boston MAUSA 02215 v, Dept Biomed Engn, Boston, MA 02215 USA Kyoto Univ Hosp, Dept Phys Therapeut, Kyoto 6068507, Japan Kyoto Univ Hosp Kyoto Japan 6068507 Phys Therapeut, Kyoto 6068507, Japan Kyoto Univ Hosp, Dept Pulm Med, Kyoto 6068507, Japan Kyoto Univ Hosp Kyoto Japan 6068507 Dept Pulm Med, Kyoto 6068507, Japan Kyoto Univ Hosp, Dept Radiol, Kyoto 6068507, Japan Kyoto Univ Hosp KyotoJapan 6068507 p, Dept Radiol, Kyoto 6068507, Japan McGill Univ, Meakins Christie Labs, Montreal, PQ H2X 2P2, Canada McGill Univ Montreal PQ Canada H2X 2P2 Labs, Montreal, PQ H2X 2P2, Canada
Titolo Testata:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
fascicolo: 16, volume: 96, anno: 1999,
pagine: 8829 - 8834
SICI:
0027-8424(19990803)96:16<8829:COTAGA>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRACTAL ANALYSIS; BRONCHIAL TREE; BLOOD-FLOW; EMPHYSEMA; HETEROGENEITY; DIAGNOSIS; DIAMETER; BRANCHES; AREAS; CT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Suki, B Boston Univ, Dept Biomed Engn, 44 Cummington St, Boston, MA 02215 USA Boston Univ 44 Cummington St Boston MA USA 02215 ton, MA 02215 USA
Citazione:
M. Mishima et al., "Complexity of terminal airspace geometry assessed by lung computed tomography in normal subjects and patients with chronic obstructive pulmonary disease", P NAS US, 96(16), 1999, pp. 8829-8834

Abstract

Increases in the low attenuation areas (LAA) of chest x-ray computed tomography images in patients with chronic obstructive pulmonary disease (COPD) have been reported to reflect the development of pathological emphysema, weexamined the statistical properties of LAA clusters in COPD patients and in healthy subjects. In COPD patients, the percentage of the lung field occupied by LAAs (LAA%) ranged from 2.6 to 67.6. In contrast, LAA% was always <30% in healthy subjects. The cumulative size distribution of the WA clusters followed a power law characterized by an exponent D. We show that D is a measure of the complexity of the terminal airspace geometry. The COPD patients with normal LAA% had significantly smaller D values than the healthy subjects, and the D values did not correlate with pulmonary function tests except for the diffusing capacity of the lung. We interpret these results by using a large elastic spring network model and find that the neighboring smaller LAA clusters tend to coalesce and form larger clusters as the weak elastic fibers separating them break under tension. This process leaves LAA% unchanged whereas it decreases the number of small clusters and increases the number of large clusters, which results in a reduction in D similar to that observed in early emphysema patients. These findings suggest that D is a sensitive and powerful parameter for the detection of the terminal airspace enlargement that occurs in early emphysema.

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Documento generato il 23/01/20 alle ore 06:18:39