Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
A new variant CYP2D6 allele (CYP2D6*21) with a single base insertion in exon 5 in a Japanese population associated with a poor metabolizer phenotype
Autore:
Chida, M; Yokoi, T; Nemoto, N; Inaba, M; Kinoshita, M; Kamataki, T;
Indirizzi:
Hokkaido Univ, Grad Sch Pharmaceut Sci, Lab Drug Metab, Div Pharmacobiodynam,Kita Ku, Sapporo, Hokkaido 0600812, Japan Hokkaido Univ Sapporo Hokkaido Japan 0600812 oro, Hokkaido 0600812, Japan Toyama Med & Pharmaceut Univ, Fac Pharmaceut Sci, Dept Toxicol, Toyama, Japan Toyama Med & Pharmaceut Univ Toyama Japan , Dept Toxicol, Toyama, Japan Otsuka Pharmaceut Co Ltd, Tokushima 77101, Japan Otsuka Pharmaceut Co LtdTokushima Japan 77101 d, Tokushima 77101, Japan Japanese Fdn Canc Res, Ctr Canc Chemotherapy, Tokyo 170, Japan Japanese Fdn Canc Res Tokyo Japan 170 anc Chemotherapy, Tokyo 170, Japan
Titolo Testata:
PHARMACOGENETICS
fascicolo: 3, volume: 9, anno: 1999,
pagine: 287 - 293
SICI:
0960-314X(199906)9:3<287:ANVCA(>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENETIC-POLYMORPHISM; SPARTEINE METABOLISM; CHINESE SUBJECTS; DRUG-METABOLISM; DEBRISOQUINE; OXIDATION; HYDROXYLATION; LOCUS; IDENTIFICATION; AMPLIFICATION;
Keywords:
CYP2D6*3; CYP2D6*4; CYP2D6*5; CYP2D6*18; genotype;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Kamataki, T Hokkaido Univ, Grad Sch Pharmaceut Sci, Lab Drug Metab, Div Pharmacobiodynam,Kita Ku, N12W6, Sapporo, Hokkaido 0600812, Japan Hokkaido Univ N12W6 Sapporo Hokkaido Japan 0600812 0812, Japan
Citazione:
M. Chida et al., "A new variant CYP2D6 allele (CYP2D6*21) with a single base insertion in exon 5 in a Japanese population associated with a poor metabolizer phenotype", PHARMACOGEN, 9(3), 1999, pp. 287-293

Abstract

Two poor metabolizer individuals of debrisoquine were identified among 215healthy Japanese by a phenotyping test, Analysis of the CYP2D6 gene from one of two poor metabolizers, who was not homozygous for the previously described CYP2D6 Variant alleles (CYP2D6*3, CYP2D6*4, CYP2D6*5 and CYP2D6*18), showed that this individual was heterozygous for a new allele, CYP2D6/C8 (CYP2D6*21), CYP2D6*21 I had a single cytosine insertion at position 2661 in exon 5, This cytosine insertion generated a stop codon at the 17 bp downstream of this insertion site, A method to detect this allele was established with an allele specific-polymerase chain reaction, This method showed that another one of two poor metabolizers also possessed CYP2D6*21 allele heterozygously, In 318 healthy Japanese, five individuals carried this allele, heterozygously (0.81%, 5/636 chromosomes), Based on the present and our previous data, the poor metabolizer frequency in Japanese was estimated to be 0.39%, which accounted for approximately 45% of the individuals phenotyped aspoor metabolizers by in-vivo tests. Pharmacogenetics 9:287-293 (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 01:55:55