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Titolo:
Des-Arg(9)-bradykinin metabolism in patients who presented hypersensitivity reactions during hemodialysis: role of serum ACE and aminopeptidase P
Autore:
Blais, C; Marc-Aurele, J; Simmons, WH; Loute, G; Thibault, P; Skidgel, RA; Adam, A;
Indirizzi:
Univ Montreal, Fac Pharm, Montreal, PQ H3C 3J7, Canada Univ Montreal Montreal PQ Canada H3C 3J7 rm, Montreal, PQ H3C 3J7, Canada Hop Sacre Coeur, Montreal, PQ H4J 1C5, Canada Hop Sacre Coeur Montreal PQCanada H4J 1C5 , Montreal, PQ H4J 1C5, Canada Loyola Univ, Stritch Sch Med, Dept Mol & Cellular Biochem, Maywood, IL 60153 USA Loyola Univ Maywood IL USA 60153 Cellular Biochem, Maywood, IL 60153 USA Ctr Hosp St Ode, B-6680 St Ode, Belgium Ctr Hosp St Ode St Ode Belgium B-6680 osp St Ode, B-6680 St Ode, Belgium Conseil Natl Rech Canada, Inst Biol Sci, Ottawa, ON K1A 0R6, Canada Conseil Natl Rech Canada Ottawa ON Canada K1A 0R6 awa, ON K1A 0R6, Canada Univ Illinois, Dept Pharmacol, Lab Peptide Res, Coll Med, Chicago, IL 60612 USA Univ Illinois Chicago IL USA 60612 e Res, Coll Med, Chicago, IL 60612 USA
Titolo Testata:
PEPTIDES
fascicolo: 4, volume: 20, anno: 1999,
pagine: 421 - 430
SICI:
0196-9781(1999)20:4<421:DMIPWP>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANGIOTENSIN-CONVERTING-ENZYME; ANAPHYLACTOID REACTIONS; BRADYKININ DEGRADATION; DIALYSIS MEMBRANES; ETHYLENE-OXIDE; AN69 MEMBRANES; BOVINE LUNG; RAT LUNG; INHIBITORS; PURIFICATION;
Keywords:
kinin metabolism; hypersensitivity reactions; hemodialysis; angiotensin-converting enzyme inhibitor; aminopeptidase P;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Adam, A Univ Montreal, Fac Pharm, Montreal, PQ H3C 3J7, Canada Univ Montreal Montreal PQ Canada H3C 3J7 real, PQ H3C 3J7, Canada
Citazione:
C. Blais et al., "Des-Arg(9)-bradykinin metabolism in patients who presented hypersensitivity reactions during hemodialysis: role of serum ACE and aminopeptidase P", PEPTIDES, 20(4), 1999, pp. 421-430

Abstract

Bradykinin (BK) has been proposed as the principal mediator of hypersensitivity reactions (HSR) in patients dialyzed using negatively charged membranes and concomitantly treated with angiotensin-converting enzyme (ACE) inhibitors. We investigated the metabolism of exogenous BK added to the sera of 13 patients dialyzed on an AN69 membrane with a history of HSR (HSR+ patients) and 10 others who did not present such a reaction (HSR-patients) while dialyzed under the same conditions. No significant difference in the t(1/2)of BK was found between the patient groups. However, the t(1/2) of generated des-Arg(9)-BK was significantly increased (2.2-fold) in HSR+ patients compared to HSR-subjects. Preincubation of the sera with an ACE inhibitor (enalaprilat) significantly increased the t(1/2) of both BK and des-Arg(9)-BK in both groups. There was no significant difference between the groups withrespect to the t(1/2) of BK, but there was a significantly greater increase (3.8-fold) in the t(1/2) of des-Arg(9)-BK in HSR+ patients compared to HSR-subject. The level of serum aminopeptidase P (APP) activity showed a significant decrease in the HSR+ sera when compared to HSR-samples. In HSR-and HSR+ patients, a significant inverse relation (r(2) = 0.6271; P < 0.00005) could be calculated between APP activity and des-Arg(9)-BK t(1/2). In conclusion, HSR in hemodialyzed patients who are concomitantly treated with a negatively charged membrane and an ACE inhibitor can be considered as a multifactorial disease in that a decreased APP activity resulting in reduced degradation of des-Arg(9)-BK may lead to the accumulation of this B-1 agonist that could be responsible, at least in part, for the signs and symptoms of HSR. (C) 1999 Elsevier Science Inc. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 03:45:10