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Titolo:
The relationship between circulating and intestinal Heligmosomoides polygyrus-specific IgG(1) and IgA and resistance to primary infection
Autore:
Ben-Smith, A; Wahid, FN; Lammas, DA; Behnke, JM;
Indirizzi:
Univ Birmingham, Sch Med, MRC, Ctr Immune Regulat,Dept Immunol, BirminghamB15 2TT, W Midlands, England Univ Birmingham Birmingham W Midlands EnglandB15 2TT W Midlands, England Univ Nottingham, Dept Life Sci, Nottingham NG7 2RD, England Univ Nottingham Nottingham England NG7 2RD , Nottingham NG7 2RD, England
Titolo Testata:
PARASITE IMMUNOLOGY
fascicolo: 8, volume: 21, anno: 1999,
pagine: 383 - 395
SICI:
0141-9838(199908)21:8<383:TRBCAI>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY RESPONSE PHENOTYPE; NEMATOSPIROIDES-DUBIUS; IMMUNOLOGICAL RELATIONSHIPS; ADULT WORMS; MICE; ANTIBODY; SERUM; EXPULSION; IMMUNITY; STRAINS;
Keywords:
Heligmosomoides polygyrus; nematoda; mice; IgG antibody; IgA antibody;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Ben-Smith, A Univ Birmingham, Sch Med, MRC, Ctr Immune Regulat,Dept Immunol, BirminghamB15 2TT, W Midlands, England Univ Birmingham Birmingham W Midlands England B15 2TT ngland
Citazione:
A. Ben-Smith et al., "The relationship between circulating and intestinal Heligmosomoides polygyrus-specific IgG(1) and IgA and resistance to primary infection", PARASITE IM, 21(8), 1999, pp. 383-395

Abstract

Specific serum and intestinal immunoglobulin (Ig)G(1) and IgA responses toHeligmosomoides polygyrus wc re measured in a panel of seven inbred mouse strains which exhibit 'rapid' (<6 weeks (SWRxSJL)F-1), 'fast' (< 8 weeks, SJL and SWR), 'intermediate' (10-20 weeks, NIH and BALB/c) or 'slow' (>25 weeks, C57BL/10 and CBA) resolution of primary infections. Mice with 'rapid',fast' or 'intermediate' response phenotypes produced greater serum and intestinal antibody responses than those with 'slow' phenotypes. The F-1 hybrids ((SWR x SJL)F-1) of two fast' responder strains showed the earliest antibody response with maximum titres evident within 6 weeks of infection. There was a negative correlation between the serum IgG(1) responses and worm burdens in individual mice within a number of mouse strains, and also betweenserum IgG(1) and IgA responses and worm burdens in the 'rapid' ((SWR x SJL)F-1) responder strain. The presence off IgG(1) in the gut was found to be due to local secretion rather than plasma leakage. Using Western immunoblotting, serum IgG(1) from 'rapid' and 'fast' responder but not 'slow' responder mice was found to react with low molecular weight antigens (16-18 kDa) in adult worm excretory/secretory products.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:23:37