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Titolo:
Association of VDR and estrogen receptor genotypes with bone mass in postmenopausal Caucasian women: Different conclusions with different analyses and the implications
Autore:
Deng, HW; Li, J; Li, JL; Johnson, M; Gong, G; Recker, RR;
Indirizzi:
Creighton Univ, Dept Biomed Sci, Omaha, NE 68131 USA Creighton Univ OmahaNE USA 68131 v, Dept Biomed Sci, Omaha, NE 68131 USA
Titolo Testata:
OSTEOPOROSIS INTERNATIONAL
fascicolo: 6, volume: 9, anno: 1999,
pagine: 499 - 507
SICI:
0937-941X(1999)9:6<499:AOVAER>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE-TRAIT LOCI; FRAGMENT-LENGTH-POLYMORPHISM; DISCORDANT SIB PAIRS; MINERAL DENSITY; GENE POLYMORPHISMS; OSTEOPOROTIC FRACTURES; PREMENOPAUSAL WOMEN; JAPANESE WOMEN; WHITE WOMEN; ALLELES;
Keywords:
bone mineral density; distal radius; estrogen receptor genotypes; femoral neck; spine; total body bone mass; vitamin D receptor genotypes;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Deng, HW Creighton Univ, Osteoporosis Res Ctr, Dept Med, 601 N 30th St, Omaha, NE 68131 USA Creighton Univ 601 N 30th St Omaha NE USA 68131 aha, NE 68131 USA
Citazione:
H.W. Deng et al., "Association of VDR and estrogen receptor genotypes with bone mass in postmenopausal Caucasian women: Different conclusions with different analyses and the implications", OSTEOPOR IN, 9(6), 1999, pp. 499-507

Abstract

Much work has been done on the association between vitamin D receptor (VDR) genotypes and bone mineral density (BMD). Despite considerable effort, the results are inconsistent. While the VDR association remains unresolved, studies have expanded to other candidate genes (i.e., estrogen receptor (ER)genotypes), also yielding inconsistent results. A few studies have suggested that interaction effects between VDR and ER genotypes significantly affect BMD. We assessed associations of BMD with VDR BsmI. genotypes, and ER XbaI and PvuII polymorphisms (denoted as ERX and ERP respectively) with spine, femoral neck, distal radius BMD, and with total body bone mineral content(tbBMC) in 108 US Mid-western postmenopausal Caucasian women. We statistically controlled for confounding factors such as height, weight, etc., in the analysis. No significant association was detected for ER genotypes with spine and radius BMD, or for VDR genotypes with femoral neck and radius BMD and tbBMC. No significant interaction between VDR and ER genotypes was detected in our sample. However, the VDR genotypes are significantly (p = 0.004) associated with similar to 5.8% spine BMD variation. Both ERX and ERP genotypes are significantly (p = 0.02) associated with similar to 3.5% femoralneck BMD variation. ERX genotypes are significantly (p = 0.03) associated with similar to 2.4% tbBMC variation. However, if the data were analyzed bysimple ANOVA as in some previous studies, without adjusting statistically for confounding factors, all the significant results we found here would have gone undetected. Our findings suggest that: (1) VDR and ER genotypes mayhave different effects on BMD at different sites and on tbBMC; and (2) if significant factors influencing bone are not appropriately controlled, truesignificant associations can easily be missed. These findings may offer a partial explanation for some of the earlier inconsistent results of association studies on BMD with VDR and ER genotypes.

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Documento generato il 04/04/20 alle ore 13:55:44