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Titolo:
Long-term synaptic changes induced by intracellular tetanization of CA3 pyramidal neurons in hippocampal slices from juvenile rats
Autore:
Berretta, N; Rossokhin, AV; Cherubini, E; Astrelin, AV; Voronin, LL;
Indirizzi:
Russian Acad Sci, Inst Brain Res, Moscow 103064, Russia Russian Acad Sci Moscow Russia 103064 t Brain Res, Moscow 103064, Russia Sch Adv Int Studies, Biophys Sector, I-34014 Trieste, Italy Sch Adv Int Studies Trieste Italy I-34014 Sector, I-34014 Trieste, Italy Int Sch Adv Studies, INFM Unit, I-34014 Trieste, Italy Int Sch Adv Studies Trieste Italy I-34014 M Unit, I-34014 Trieste, Italy Moscow State Univ, Dept Mech & Math, Moscow 119899, Russia Moscow State Univ Moscow Russia 119899 ech & Math, Moscow 119899, Russia
Titolo Testata:
NEUROSCIENCE
fascicolo: 2, volume: 93, anno: 1999,
pagine: 469 - 477
SICI:
0306-4522(1999)93:2<469:LSCIBI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
PAIRED-PULSE FACILITATION; MOSSY-FIBER SYNAPSES; EXCITATORY POSTSYNAPTIC POTENTIALS; PERFORATED PATCH-CLAMP; QUANTAL ANALYSIS; PRESYNAPTIC INVOLVEMENT; SILENT SYNAPSES; MAMMALIAN BRAIN; VISUAL-CORTEX; AREA CA1;
Keywords:
long-term depression; long-term potentiation; postnatal development; excitatory postsynaptic potentials; quantal analysis; paired-pulse facilitation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
76
Recensione:
Indirizzi per estratti:
Indirizzo: Voronin, LL Russian Acad Sci, Inst Brain Res, Moscow 103064, Russia Russian Acad Sci Moscow Russia 103064 Moscow 103064, Russia
Citazione:
N. Berretta et al., "Long-term synaptic changes induced by intracellular tetanization of CA3 pyramidal neurons in hippocampal slices from juvenile rats", NEUROSCIENC, 93(2), 1999, pp. 469-477

Abstract

Minimal excitatory postsynaptic potentials were evoked in CA3 pyramidal neurons by activation of the mossy fibres in hippocampal slices from seven- to 16-day-old rats. Conditioning intracellular depolarizing pulses were delivered as 50- or 100-Hz bursts. A statistically significant depression and potentiation was induced in four and five of 13 cases, respectively. The initial state of the synapses influenced the effect: the amplitude changes correlated with the pretetanic paired-pulse facilitation ratio. Afferent (mossy fibre) tetanization produced a significant depression in four of six inputs, and no significant changes in two inputs. Quantal content decreased or increased following induction of the depression or potentiation, respectively, whereas no significant changes in quantal size were observed. Compatible with presynaptic maintenance mechanisms of both depression and potentiation, changes in the mean quantal content were associated with modifications in the paired-pulse facilitation ratios, coefficient of variation of response amplitudes and number of response failures. Cases were encountered when apparently "presynaptically silent" synapses were converted into functionalsynapses during potentiation or when effective synapses became "presynaptically silent" when depression was induced, suggesting respective changes inthe probability of transmitter release. It is concluded that, in juvenile rats, it is possible to induce lasting potentiation at the mossy fibre-CAS synapses by purely postsynaptic stimulation, while afferent tetanization is accompanied by long-lasting depression. The data support the existence not only of a presynaptically induced, but also a postsynaptically induced form of long-term potentiation in the mossyfibre-CA3 synapse. Despite a postsynaptic induction mechanism, maintenanceof both potentiation and depression is likely to occur presynaptically. (C) 1999 IBRO. Published by Elsevier Science Ltd.

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Documento generato il 29/09/20 alle ore 23:16:02