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Titolo:
Desmin phosphorylation abnormalities in cytoplasmic body and desmin-related myopathies
Autore:
Caron, A; Chapon, F;
Indirizzi:
Ctr Hosp Reg & Univ Caen, Neuropathol Lab, F-14033 Caen, France Ctr Hosp Reg & Univ Caen Caen France F-14033 l Lab, F-14033 Caen, France
Titolo Testata:
MUSCLE & NERVE
fascicolo: 8, volume: 22, anno: 1999,
pagine: 1122 - 1125
SICI:
0148-639X(199908)22:8<1122:DPAICB>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-B-CRYSTALLIN; INTERMEDIATE FILAMENTS; HEAD DOMAIN; MYOFIBRILLAR MYOPATHY; SKELETAL-MUSCLE; ACCUMULATION; PROTEINS; BODIES; ACTIN; CARDIOMYOPATHY;
Keywords:
cytoplasmic body myopathy; desmin-related myopathy; desmin phosphorylation; two-dimensional electrophoresis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Chapon, F Ctr Hosp Reg & Univ Caen, Neuropathol Lab, Cote de Nacre, F-14033 Caen, France Ctr Hosp Reg & Univ Caen Cote de Nacre Caen France F-14033 ance
Citazione:
A. Caron e F. Chapon, "Desmin phosphorylation abnormalities in cytoplasmic body and desmin-related myopathies", MUSCLE NERV, 22(8), 1999, pp. 1122-1125

Abstract

Cytoplasmic body myopathy (CBM) and desmin-related myopathy (DRM) are bothcharacterized by an abnormal accumulation of desmin. To determine whether these abnormalities involve similar or different forms of desmin, we performed desmin two-dimensional electrophoresis: our results showed an increase in the two acidic isoforms in CBM muscles as compared with an increase in the number of acidic isovariants in DRM samples. A process of hyperphosphorylation involved in these acidic forms was confirmed by alkaline phosphataseapplication onto the muscle samples in both pathological conditions. (C) 1999 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 02:39:40