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Titolo:
Growth inhibition of Candida albicans by vaginal cells from naive mice
Autore:
Steele, C; Ozenci, H; Luo, W; Scott, M; Fidel, PL;
Indirizzi:
Louisiana State Univ, Med Ctr, Dept Microbiol Immunol & Parasitol, New Orleans, LA 70112 USA Louisiana State Univ New Orleans LA USA 70112 , New Orleans, LA 70112 USA
Titolo Testata:
MEDICAL MYCOLOGY
fascicolo: 4, volume: 37, anno: 1999,
pagine: 251 - 259
SICI:
1369-3786(199908)37:4<251:GIOCAB>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTESTINAL EPITHELIAL-CELLS; POLYMORPHONUCLEAR NEUTROPHILS; ANTIGEN PRESENTATION; T-LYMPHOCYTES; IMMUNITY; RECURRENT; INVITRO; SUSCEPTIBILITY; RESPONSES; VAGINITIS;
Keywords:
Candida albicans; epithelial cells; vaginal mucosa; vaginitis;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Fidel, PL Louisiana State Univ, Med Ctr, Dept Microbiol Immunol & Parasitol, 1901 Perdido St, New Orleans, LA 70112 USA Louisiana State Univ 1901 Perdido St New Orleans LA USA 70112 SA
Citazione:
C. Steele et al., "Growth inhibition of Candida albicans by vaginal cells from naive mice", MED MYCOL, 37(4), 1999, pp. 251-259

Abstract

Recurrent vulvovaginal candidiasis (RVVC) is a common idiopathic mucosal infection caused by Candida albicans. Current data suggests that local immunity is more important than that in the peripheral circulation for protection against infection. In the present study, anti-Candida innate resistance at the vaginal mucosa was investigated using a murine model. For this, splenic and vaginal cells were assessed for ir? vitro growth inhibition (GI) of C. albicans and cytotoxicity of natural killer (NK) cell-sensitive tumour targets (YAC-1). As expected, significant GI of C. albicans by splenic cellswas mediated predominantly by polymorphonuclear leucocytes (PMNL) at effector to target (E:T) ratios of 100 and 50.1. From the vaginal mucosa, naive unfractionated, but not nylon wool non-adherent (NWN), cells extracted fromwhole vaginal tissue showed significant GI of C. albicans at E:T ratios aslow as 1:1, but only modest killing of YAC-1 targets at all E:T ratios. Subsequent experiments showed significant GI of C, albicans by vaginal epithelioid-enriched cells and with several epithelial cell lines, but not in supernatants collected from the co-cultures. In contrast, lymphoid cell lines had no anti-Candida activity. These results suggest that anti-Candida activity is present at the vaginal mucosa, but unlike that from the spleen, the vaginal activity appears to be predominantly mediated by epithelial cells.

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Documento generato il 15/07/20 alle ore 14:02:10