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Titolo:
Prolactin blocks glucocorticoid induced cell death by inhibiting the disruption of the mitochondrial membrane
Autore:
Weimann, E; Baixeras, E; Zamzami, N; Kelly, P;
Indirizzi:
INSERM U344, F-75015 Paris, France INSERM U344 Paris France F-75015INSERM U344, F-75015 Paris, France CNRS UPR 420, F-94801 Villejuif, France CNRS UPR 420 Villejuif France F-94801 UPR 420, F-94801 Villejuif, France
Titolo Testata:
LEUKEMIA RESEARCH
fascicolo: 8, volume: 23, anno: 1999,
pagine: 751 - 762
SICI:
0145-2126(199908)23:8<751:PBGICD>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
NB2 LYMPHOMA-CELLS; INDUCED APOPTOSIS; BCL-2; ACTIVATION; SURVIVAL; PROTEASE; TRANSFORMATION; PROLIFERATION; POLYMERASE; INDUCTION;
Keywords:
apoptosis; prolactin; dexamethasone; mitochondrial transmembrane potential; bcl-2; ICE-like proteases;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
33
Recensione:
Indirizzi per estratti:
Indirizzo: Weimann, E Univ Frankfurt, Clin Paediat Endocrinol & Metab, Med Ctr Child Hlth, Theodor Stern Kai 7, D-60590 Frankfurt, Germany Univ Frankfurt Theodor Stern Kai 7 Frankfurt Germany D-60590 y
Citazione:
E. Weimann et al., "Prolactin blocks glucocorticoid induced cell death by inhibiting the disruption of the mitochondrial membrane", LEUK RES, 23(8), 1999, pp. 751-762

Abstract

Prolactin (PRL) has been reported to inhibit dexamethasone (Dex) induced cell death. Nevertheless, the mechanism through which PRL exerts its protective effect is still not unravelled. Here, we analyse the effect of PRL at different stages of the glucocorticoid (GC) apoptotic pathway in PRL dependent cells (Nb, cells). PRL blocks completely the GC induced loss of the mitochondrial transmembrane potential (Delta Psi(m))and consequently phosphatidylserine (PS) exposure and loss of DNA content. Although PRL promotes an upregulation of the bcl-2 expression, simultaneous addition of PRL to GC fails to maintain even the normal levels of this anti-apoptotic protein. This finding excludes a critical role for bcl-2 in the PRL protective effect against GC. GC induced Delta Psi(m) disruption can be inhibited by the ICE-likeinhibitor zVAD-fmk but not by ICE inhibitor tetrapeptide acetyl-Tyr-Val-Ala-Asp.chloromethylketon (YVAD-cmk) nor by caspase-3 inhibitor zDEVD. It canbe speculated that PRL blocks Delta Psi(m), disruption by inhibiting an unknown caspase activated by GC. (C) 1999 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 13:13:41