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Titolo:
Dual mechanism for presynaptic modulation by axonal metabotropic glutamatereceptor at the mouse mossy fibre-CA3 synapse
Autore:
Kamiya, H; Ozawa, S;
Indirizzi:
Gunma Univ, Sch Med, Dept Physiol, Gunma 3718511, Japan Gunma Univ GunmaJapan 3718511 h Med, Dept Physiol, Gunma 3718511, Japan
Titolo Testata:
JOURNAL OF PHYSIOLOGY-LONDON
fascicolo: 2, volume: 518, anno: 1999,
pagine: 497 - 506
SICI:
0022-3751(19990715)518:2<497:DMFPMB>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; NEONATAL RAT HIPPOCAMPUS; CA2+ CHANNELS; NEUROTRANSMITTER RELEASE; CALCIUM CHANNELS; FIBER SYNAPSES; AREA CA1; TRANSMISSION; INHIBITION; INFLUX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Kamiya, H Gunma Univ, Sch Med, Dept Physiol, 3-39-22 Showa Machi, Gunma 3718511, Japan Gunma Univ 3-39-22 Showa Machi Gunma Japan 3718511 18511, Japan
Citazione:
H. Kamiya e S. Ozawa, "Dual mechanism for presynaptic modulation by axonal metabotropic glutamatereceptor at the mouse mossy fibre-CA3 synapse", J PHYSL LON, 518(2), 1999, pp. 497-506

Abstract

1. To investigate mechanisms responsible fbr the presynaptic inhibitory action mediated by the axonal group II metabotropic glutamate receptor (mGluR) at the mossy fibre-CA3 synapse, we used a quantitative fluorescence measurement of prresynaptic Ca2+ in mouse hippocampal slices.2. Bath application of the group II mGluR-specific agonist (2S,1'R,2'R,3'R)-2-(2,3-dicarboxycyclopropyl)glycine (DCG-IV, 1 mu M) reversibly suppressed the presynaptic Ca2+ influx (to 55.2 +/- 4.6% of control, n = 5) as well as field EPSPs recorded simultaneously (to 3.1 +/- 2.0%). Presynaptic fibrevolley was not affected by 1 mu M DCG-IV.3. A quantitative analysis of the inhibition of presynaptic Ca2+ influx and field EPXP suggested that DCG-IV suppressed the field EPSP to a greater extent than would be expected if the suppression were solely due to a decrease in the presynaptic Ca2+ influx.4. DCG-IV at 1 mu M suppressed the mean frequency (to 73.8 +/- 3.9% of control, n = 11), but not the mean amplitude (to 97.0 +/- 3.5%), of miniature EPSCs recorded from CA3 neurones using the whole-cell patch-clamp technique.5. These results suggest that group II mGluR-mediated suppression is due both to a reduction of presynaptic Ca2+ influx and downregulation of the subsequent exocytotic machinery.

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Documento generato il 21/09/20 alle ore 12:47:21