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Titolo:
Neuregulins and ErbB receptors in cultured neonatal astrocytes
Autore:
Francis, A; Raabe, TD; Wen, DZ; DeVries, GH;
Indirizzi:
US Dept Vet Affairs, Vet Affairs Edward Hines Jr Hosp, Res Serv 151, Hines, IL 60141 USA US Dept Vet Affairs Hines IL USA 60141 Res Serv 151, Hines, IL 60141 USA Loyola Univ, Med Ctr, Dept Cell Biol Neurobiol & Anat, Maywood, IL 60153 USA Loyola Univ Maywood IL USA 60153 Neurobiol & Anat, Maywood, IL 60153 USA Loyola Univ, Med Ctr, Grad Program Neurosci, Maywood, IL 60153 USA Loyola Univ Maywood IL USA 60153 Program Neurosci, Maywood, IL 60153 USA St Marys Univ, Dept Biol Sci, San Antonio, TX USA St Marys Univ San Antonio TX USA niv, Dept Biol Sci, San Antonio, TX USA Amgen Inc, Thousand Oaks, CA 91320 USA Amgen Inc Thousand Oaks CA USA 91320 gen Inc, Thousand Oaks, CA 91320 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE RESEARCH
fascicolo: 4, volume: 57, anno: 1999,
pagine: 487 - 494
SICI:
0360-4012(19990815)57:4<487:NAERIC>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEU DIFFERENTIATION FACTOR; EPIDERMAL GROWTH-FACTOR; SECRETE NEUREGULINS; SIGNAL-TRANSDUCTION; NERVOUS-SYSTEM; SCHWANN-CELLS; GLIAL-CELLS; EXPRESSION; PROTEIN; BRAIN;
Keywords:
growth factor; autocrine; neuregulin; astrocyte; erbB receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: DeVries, GH US Dept Vet Affairs, Vet Affairs Edward Hines Jr Hosp, Res Serv 151, Roosevelt Rd & 5th Ave, Hines, IL 60141 USA US Dept Vet Affairs Roosevelt Rd & 5th Ave Hines IL USA 60141
Citazione:
A. Francis et al., "Neuregulins and ErbB receptors in cultured neonatal astrocytes", J NEUROSC R, 57(4), 1999, pp. 487-494

Abstract

Neuregulins (NRGs) are a family of growth factors involved in signaling between neurons and glial cells of the peripheral and central nervous system,NRGs are synthesized and secreted by a number of cell types including Schwann cells, neurons, and oligodendrocytes, NRG transduction signals are mediated by the erbB family of receptor tyrosine kinases, These NRGs may be important for paracrine or autocrine signaling during development, injury, andthe normal functioning of the central nervous system. In this study, we characterize the NRGs and erbB receptors expressed by cultured neonatal rat astrocytes, Using immunoblotting protocols With pan-specific antibodies, we identified eleven NRG molecular weight isoforms from approximately 16 kDa to 105 kDa in cultured neonatal rat astrocytes, Immunocyotchemistry with isoform-specific antibodies revealed the expression of both major isoform families (NRG alpha, NRG beta), Additionally, astrocyte-conditioned media contained two molecular weight isoforms of NRGs, We detected mRNA expression of NRG alpha and NRG beta in astrocytes by amplifying mRNA transcripts with reverse transcription polymerase chain reaction. Furthermore, we confirm thatcultured astrocytes express all four erbB receptors as detected by immunocytochemical and immunoblotting techniques, These data indicate that astrocytes contain and secrete NRGs. (C) 1999 Wiley-Liss,Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 14:55:13