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Titolo:
Risperidone treatment of behavioral disturbances in outpatients with dementia
Autore:
Irizarry, MC; Ghaemi, SN; Lee-Cherry, ER; Gomez-Isla, T; Binetti, G; Hyman, BT; Growdon, JH;
Indirizzi:
Harvard Univ, Sch Med, Massachusetts Gen Hosp, Dept Neurol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Hosp, Dept Neurol, Boston, MA 02115 USA George Washington Univ, Dept Psychiat, Ctr Neurosci Med Progress & Soc, Washington, DC USA George Washington Univ Washington DC USA gress & Soc, Washington, DC USA
Titolo Testata:
JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES
fascicolo: 3, volume: 11, anno: 1999,
pagine: 336 - 342
SICI:
0895-0172(199922)11:3<336:RTOBDI>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROLEPTIC MALIGNANT SYNDROME; ALZHEIMERS-DISEASE; EXTRAPYRAMIDAL SYMPTOMS; REUPTAKE INHIBITORS; MOVEMENT-DISORDERS; CLOZAPINE; PSYCHOSIS; EFFICACY; SIGNS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Irizarry, MC Massachusetts Gen Hosp E, Alzheimer Dis Res Unit, CNY 6028,149 13th St, Cambridge, MA 02139 USA Massachusetts Gen Hosp E CNY 6028,149 13th St Cambridge MA USA 02139
Citazione:
M.C. Irizarry et al., "Risperidone treatment of behavioral disturbances in outpatients with dementia", J NEUROP CL, 11(3), 1999, pp. 336-342

Abstract

The authors retrospectively assessed the effectiveness and side effects ofrisperidone used to trent behavioral disturbances in elderly outpatients with dementia. In 41 patients treated with risperidone 1.8 +/- 1.4 mg/day, there was complete suppression of the target symptom in 15%, partial response in 41%, and no response in 44%. Risperidone appeared equally effective intreating agitation and psychosis. New or worsening extra-pyramidal side effects (EPS) occurred in 32%, associated with longer duration of treatment and possibly with concomitant use of serotonergic antidepressants. Risperidone was a useful adjunct in the treatment of agitation and psychosis in outpatients with dementia but teas limited by EPS in about one-third of patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:17:08