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Titolo:
Serotoninergic and suprachiasmatic nucleus involvement in the corticotropic response to systemic endotoxin challenge in rats
Autore:
Givalois, L; Becq, H; Siaud, P; Ixart, G; Assenmacher, I; Barbane, G;
Indirizzi:
Univ Montpellier 2, Cerebral Plast Lab, CNRS, EP 628, F-34095 Montpellier,France Univ Montpellier 2 Montpellier France F-34095 F-34095 Montpellier,France Fac Med Nord, Lab Interact Cellulaires Neuroendocriniennes, CNRS, UMR 6544, Marseille, France Fac Med Nord Marseille France iennes, CNRS, UMR 6544, Marseille, France Fac Med Nord, Lab Interact Fonct & Neuroendocrinol, INSERM, U501, Marseille, France Fac Med Nord Marseille France docrinol, INSERM, U501, Marseille, France Univ Montpellier 2, Dept Biol Sante, F-34095 Montpellier 5, France Univ Montpellier 2 Montpellier France 5 e, F-34095 Montpellier 5, France Ecole Natl Super Chim Montpellier, Montpellier, France Ecole Natl Super Chim Montpellier Montpellier France ontpellier, France
Titolo Testata:
JOURNAL OF NEUROENDOCRINOLOGY
fascicolo: 8, volume: 11, anno: 1999,
pagine: 629 - 636
SICI:
0953-8194(199908)11:8<629:SASNII>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
PITUITARY-ADRENAL AXIS; TUMOR-NECROSIS-FACTOR; FREELY MOVING RATS; PARAVENTRICULAR NUCLEUS; ADRENOCORTICOTROPIC HORMONE; PARA-CHLOROPHENYLALANINE; CEREBRAL CATECHOLAMINE; INDUCED ACTIVATION; LOCOMOTOR-ACTIVITY; NEURONAL-ACTIVITY;
Keywords:
hypothalamic-pituitary-adrenocortical axis; lipopolysaccharide; suprachiasmatic nucleus; serotonin; interleukin-1 beta;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
43
Recensione:
Indirizzi per estratti:
Indirizzo: Givalois, L Univ Montpellier 2, Cerebral Plast Lab, CNRS, EP 628, F-34095 Montpellier,France Univ Montpellier 2 Montpellier France F-34095 pellier,France
Citazione:
L. Givalois et al., "Serotoninergic and suprachiasmatic nucleus involvement in the corticotropic response to systemic endotoxin challenge in rats", J NEUROENDO, 11(8), 1999, pp. 629-636

Abstract

We have investigated whether the serotonin system participates in the mechanisms underlying the corticotropic response in experimentally infected rats. Intra-arterial injection of lipopolysaccharide (LPS; 25 mu g/kg b.w.) resulted in a slight but significant increase in serotonin (5-HT) metabolism,detectable 60 min after the stimulus and lasting more than 480 min. Adrenocorticotropin (ACTH) and corticosterone (CORT) responses in intact rats conformed to earlier reports, increasing as early as 30 min after LPS injection and reaching maximal concentrations in the circulation 60 min after the bacterial endotoxin injection. Plasma concentrations of interleukin-1 beta (IL-1 beta) increased only after 60 min, reaching maximal levels 120 min after LPS, Depletion of hypothalamic 5-HT (-93%) by pretreatment of the animals with para-chlorophenylalanine (p-CPA), resulted in a halved ACTH responseto LPS, despite an overall unchanged secretory pattern, Neither CORT nor IL-1 beta secretory patterns were affected in these rats pretreated with p-CPA. Complete bilateral electrochemical lesions of the suprachiasmatic nucleus (SCN), which is innervated by mesencephalic 5-HT, impaired the early phase of the ACTH (-75% at 30 min) and CORT (-40% at 30 min) responses but didnot affect the later increases of the corticotropic and the plasma IL-1 beta responses following the LPS injection. These results indicate that serotonin pathways and SCN are involved in the earlier mechanisms of corticotropic axis recruitment following systemic LPS endotoxemia.

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Documento generato il 19/01/20 alle ore 06:18:27