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Titolo:
Adeno-associated virus and development of cervical neoplasia
Autore:
Strickler, HD; Viscidi, R; Escoffery, C; Rattray, C; Kotloff, KL; Goldberg, J; Manns, A; Rabkin, C; Daniel, R; Hanchard, B; Brown, C; Hutchinson, M; Zanizer, D; Palefsky, J; Burk, RD; Cranston, B; Clayman, B; Shah, KV;
Indirizzi:
Yeshiva Univ Albert Einstein Coll Med, Dept Epidemiol & Social Med, Bronx,NY 10461 USA Yeshiva Univ Albert Einstein Coll Med Bronx NY USA 10461 onx,NY 10461 USA NCI, Viral Epidemiol Branch, NIH, Bethesda, MD USA NCI Bethesda MD USANCI, Viral Epidemiol Branch, NIH, Bethesda, MD USA Johns Hopkins Med Inst, Baltimore, MD 21205 USA Johns Hopkins Med Inst Baltimore MD USA 21205 st, Baltimore, MD 21205 USA Univ W Indies, Kingston 7, Jamaica Univ W Indies Kingston Jamaica 7Univ W Indies, Kingston 7, Jamaica Univ Maryland, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 iv Maryland, Baltimore, MD 21201 USA Women & Infants Hosp, Providence, RI USA Women & Infants Hosp Providence RI USA Infants Hosp, Providence, RI USA Cytyc Corp, Marlborough, MA USA Cytyc Corp Marlborough MA USACytyc Corp, Marlborough, MA USA Univ Calif San Francisco, San Francisco, CA 94143 USA Univ Calif San Francisco San Francisco CA USA 94143 ancisco, CA 94143 USA
Titolo Testata:
JOURNAL OF MEDICAL VIROLOGY
fascicolo: 1, volume: 59, anno: 1999,
pagine: 60 - 65
SICI:
0146-6615(199909)59:1<60:AVADOC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN PAPILLOMAVIRUS TYPE-16; ADENOASSOCIATED VIRUS; HERPES-SIMPLEX; BOVINE PAPILLOMAVIRUS; DNA; ANTIBODIES; PARVOVIRUS; PREVALENCE; CANCER; CELLS;
Keywords:
adeno-associated virus; AAV; cervical cancer; CIN; human papillomavirus; HPV;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Strickler, HD Yeshiva Univ Albert Einstein Coll Med, Dept Epidemiol & Social Med, 1300 Morris Pk Ave,Belfer Bldg,Rm 1308-B, Bronx, NY 10461 USA Yeshiva Univ Albert Einstein Coll Med 1300 Morris Pk Ave,Belfer Bldg,Rm 1308-B Bronx NY USA 10461
Citazione:
H.D. Strickler et al., "Adeno-associated virus and development of cervical neoplasia", J MED VIROL, 59(1), 1999, pp. 60-65

Abstract

Evidence from several sources has suggested that adeno-associated virus (AAV) infection might protect against cervical cancer, in part, by interfering with human papillomavirus (HPV)induced tumorigenesis. Detection of AAV type 2 (AAV-2) DNA in cervical tissues has been reported. However, there havebeen few in vivo studies of women with cervical HPV infection or neoplasia, and these have reported inconsistent results. Therefore, we used polymerase chain reaction (PCR) assays targeted to the AAV-2 rep and cap genes to test tissue specimens from women in an epidemiological study of cervical neoplasia in Jamaica. We tested 105 women with low-grade cervical intraepithelial neoplasia (CIN-1), 92 women with CIN-3/carcinoma in situ or invasive cancer (CIN-3/CA), and 94 normal subjects. PCR amplification of human beta-globin DNA was found in almost all cervical specimens, indicating that these materials were adequate for PCR testing. The prevalence of HPV DNA, determined by HPV L1 consensus primer PCR was, as expected, strongly associated with presence and grade of neoplasia. Each of the AAV PCR assays detected as few as 10 copies of the virus genome. However, none of the 291 cervical specimens from Jamaican subjects tested positive for AAV DNA. Negative AAV PCRresults were also obtained in tests of cervical samples from 79 universitystudents in the United States. Exposure to AAV was assessed further by serology. Using a whole virus AAV-2 sandwich enzyme-linked immunosorbent assay, we found no relationship between AAV antibodies and presence or grade of neoplasia in either the Jamaican study subjects or women enrolled in a U.S.cervical cancer case (n = 74) -control (n = 77) study. Overall, the data provide no evidence that AAV infection plays a role in cervical tumorigenesis or that AAV commonly infects cervical epithelial cells. (C) 1999 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/01/21 alle ore 07:41:56