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Titolo:
Reduction in visceral adipose tissue is associated with improvement in apolipoprotein B-100 metabolism in obese men
Autore:
Riches, FM; Watts, GF; Hua, J; Stewart, GR; Naoumova, RP; Barrett, PHR;
Indirizzi:
Univ Perth, Dept Med, Royal Perth Hosp, Perth, WA 6001, Australia Univ Perth Perth WA Australia 6001 Perth Hosp, Perth, WA 6001, Australia Univ Western Australia, Dept Med, Perth, WA 6001, Australia Univ Western Australia Perth WA Australia 6001 Perth, WA 6001, Australia Univ Western Australia, Western Australia Heart Res Inst, Perth, WA 6001, Australia Univ Western Australia Perth WA Australia 6001 Perth, WA 6001, Australia Univ Western Australia, Fac Sci, Nedlands, WA 6009, Australia Univ WesternAustralia Nedlands WA Australia 6009 nds, WA 6009, Australia Hammersmith Hosp, Imperial Coll Med, MRC, Ctr Clin Sci, London W12 0NN, England Hammersmith Hosp London England W12 0NN lin Sci, London W12 0NN, England Univ Washington, Dept Bioengn, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Dept Bioengn, Seattle, WA 98195 USA
Titolo Testata:
JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM
fascicolo: 8, volume: 84, anno: 1999,
pagine: 2854 - 2861
SICI:
0021-972X(199908)84:8<2854:RIVATI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY-LIPOPROTEIN; DEPENDENT DIABETES-MELLITUS; PLASMA MEVALONIC ACID; APO-B SECRETION; HEP G2 CELLS; CHOLESTEROL-SYNTHESIS; HEPATIC SECRETION; CARDIOVASCULAR-DISEASE; ACUTE HYPERINSULINEMIA; INSULIN RESISTANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
53
Recensione:
Indirizzi per estratti:
Indirizzo: Watts, GF Univ Perth, Dept Med, Royal Perth Hosp, Box X2213, Perth, WA 6001, Australia Univ Perth Box X2213 Perth WA Australia 6001 WA 6001, Australia
Citazione:
F.M. Riches et al., "Reduction in visceral adipose tissue is associated with improvement in apolipoprotein B-100 metabolism in obese men", J CLIN END, 84(8), 1999, pp. 2854-2861

Abstract

We investigated the effect of reduction in visceral obesity on the kinetics of apolipoprotein B-100 (apoB) metabolism in a controlled dietary intervention study in 26 obese men. Hepatic secretion of very low density lipoprotein (VLDL) apoB was measured using a primed, constant, infusion of 1-[C-13]leucine. In seven men receiving the reduction diet, intermediate density lipoprotein (IDL) and low density lipoprotein (LDL) apoB kinetics were also determined. ApoB isotopic enrichment was measured using gas chromatography-mass spectrometry, and SAAM-II was used to estimate the fractional turnover rates. Subcutaneous and visceral adipose tissues at the L3 vertebra were quantified by magnetic resonance imaging. With weight reduction there was a significant decrease (P < 0.05) in body mass index, waist circumference, andvisceral adipose tissue. The plasma concentrations of total cholesterol, triglyceride, insulin, and lathosterol also significantly decreased (P < 0.05). Compared with weight maintenance, weight reduction significantly decreased the VLDL apoB concentration, pool size, and hepatic secretion of VLDL apoB (Delta+2.5 +/- 4.6 vs. Delta-14.7 +/- 4.0 mg/kg fat free mass day; P = 0.010), but did not significantly alter its fractional catabolism. Weight reduction was also associated with an increased fractional catabolic rate ofLDL apoB (0.24 +/- 0.07 vs. 0.54 +/- 0.10 pools/day; P = 0.002) and conversion of VLDL to LDL apoB (11.7 +/- 2.58 vs. 56.3 +/- 11.4%; P = 0.008). A change in hepatic VLDL apoB secretion was significantly correlated with a change in visceral adipose tissue area (r = 0.59; P = 0.043), but not plasma concentrations of insulin, free fatty acids, or lathosterol. The data support the hypothesis that a reduction in visceral adipose tissue is associatedwith a decrease in the hepatic secretion of VLDL apoB, and this may be dueto a decrease in portal lipid substrate supply. Weight reduction may also increase the fractional catabolism of LDL apoB, but this requires further evaluation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 14:44:08