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Titolo:
Electrophysiologic and blood-flow responses in the endocardium and epicardium to disopyramide and MS-551 during myocardial ischemia in the dog
Autore:
Tanabe, T; Iwamoto, T; Iwata, O; Aikawa, M; Kusuzaki, S; Handa, S; Shinozaki, Y; Mori, H;
Indirizzi:
Tokai Univ, Sch Med, Dept Cardiovasc Med, Isehara, Kanagawa 2591193, JapanTokai Univ Isehara Kanagawa Japan 2591193 sehara, Kanagawa 2591193, Japan Tokai Univ, Sch Med, Dept Physiol, Isehara, Kanagawa 2591193, Japan Tokai Univ Isehara Kanagawa Japan 2591193 sehara, Kanagawa 2591193, Japan
Titolo Testata:
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
fascicolo: 2, volume: 34, anno: 1999,
pagine: 275 - 286
SICI:
0160-2446(199908)34:2<275:EABRIT>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY-ARTERY OCCLUSION; III ANTIARRHYTHMIC AGENT; ENTRANT VENTRICULAR ARRHYTHMIAS; NONRADIOACTIVE MICROSPHERES; INFARCTION PERIOD; CANINE MODELS; DRUGS; BLOCKADE; SOTALOL; HEMODYNAMICS;
Keywords:
dogs; disopyramide and MS-551; ischemic endocardium and epicardium electrophysiology; regional myocardial blood flow;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Mori, H Tokai Univ, Sch Med, Dept Cardiovasc Med, Shimokasuya 143, Isehara, Kanagawa 2591193, Japan Tokai Univ Shimokasuya 143 Isehara Kanagawa Japan2591193 3, Japan
Citazione:
T. Tanabe et al., "Electrophysiologic and blood-flow responses in the endocardium and epicardium to disopyramide and MS-551 during myocardial ischemia in the dog", J CARDIO PH, 34(2), 1999, pp. 275-286

Abstract

The aim of this study was to determine whether a quantitative relation exists between changes in regional myocardial blood flow (RMBF) and those in electrophysiologic determinants recorded via left ventricular endocardial and epicardial bipolar electrograms after administration of disopyramide (DP)and a class III antiarrhythmic drug, MS-551 (MS), during myocardial ischemia in the dog. Dogs were given DP (1 mg/kg, i.v., n = 14), MS (1 mg/kg, i.v., and 0.1 mg/kg/min, d.i.v., n = 13), or saline (n = 12). The effective refractory period (ERP) was determined by an S-1-S-2 extrastimulus method, and RMBF by a nonradioactive microsphere technique. The duration of regional electrograms (DRE) was measured as an indicator of conduction time in the myocardium. DP blunted ischemia-induced shortening of ERPs and lengthened DREs at the endocardial and epicardial sites, with a greater effect seen epicardially (p < 0.01 each). DP reduced RMBF, especially at the endocardial surfaces of the ischemic zone (p < 0.05). MS prolonged ERPs at the endocardial and epicardial sites in the ischemic and normal zones (p < 0.05-0.01), but there were no significant differences between the two sites. MS prolongedDREs (p < 0.05), but the magnitude of the prolongation of the DREs was similar to the values in the control group. MS had no effects on RMBF. DP treatment prolonged DREs at both sites in the ischemic zone more markedly than MS or saline treatment (p < 0.01 each). DP reduced RMBF at the endocardial site of the ischemic zone more markedly than MS or saline (p < 0.05 in each). Accordingly, MS prolonged ERPs, but did not increase disparities betweenendocardial and epicardial sites in the ischemic myocardium, whereas DP had a greater ERP-prolonging effect at the epicardial site than at the endocardial site. DP reduced endocardial RMBF more markedly than epicardial RMBF. These observations suggest that differences in ERPs between endocardial and epicardial ischemic myocardium caused by DP treatment are not due to the difference in RMBF reduction between the two tissue layers, and that DP andMS do not affect the same population of ion channel(s) when ERPs are prolonged.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/05/20 alle ore 13:22:56