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Titolo:
An iso-random BiBi mechanism for adenylate kinase
Autore:
Sheng, XR; Li, X; Pan, XM;
Indirizzi:
Acad Sinica, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples RChina Acad Sinica Beijing Peoples R China 100101 eijing 100101, Peoples RChina
Titolo Testata:
JOURNAL OF BIOLOGICAL CHEMISTRY
fascicolo: 32, volume: 274, anno: 1999,
pagine: 22238 - 22242
SICI:
0021-9258(19990806)274:32<22238:AIBMFA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ADENOSINE-TRIPHOSPHATE TRANSPHOSPHORYLASES; NUCLEAR MAGNETIC-RESONANCE; SITE-DIRECTED MUTAGENESIS; STAPHYLOCOCCAL NUCLEASE; HEMOLYTIC-ANEMIA; CRYSTALLINE RABBIT; PROLINE ISOMERISM; CALBINDIN D9K; CALF MUSCLE; X-RAY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Pan, XM Acad Sinica, Inst Biophys, Natl Lab Biomacromol, 15 Datun Rd, Beijing 100101, Peoples R China Acad Sinica 15 Datun Rd Beijing Peoples R China 100101 es R China
Citazione:
X.R. Sheng et al., "An iso-random BiBi mechanism for adenylate kinase", J BIOL CHEM, 274(32), 1999, pp. 22238-22242

Abstract

An iso-random Bi Bi mechanism has been proposed for adenylate kinase. In this mechanism, one of the enzyme forms can bind the substrates MgATP and AMP, whereas the other form can bind the products MgADP and ADP. In a catalytic cycle, the conformational changes of the free enzyme and the ternary complexes are the rate-limiting steps. The AP(5)A inhibition equations derivedfrom this mechanism show theoretically that AP(5)A acts as a competitive inhibitor for the forward reaction and a mixed noncompetitive inhibitor for the backward reaction.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 23:06:33