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Titolo:
Slowing and attenuation of baroreflex heart rate control with nitrous oxide in exercising men
Autore:
Ostlund, A; Linnarsson, D;
Indirizzi:
Karolinska Inst, Dept Physiol & Pharmacol, Sect Environm Physiol, SE-17177Stockholm, Sweden Karolinska Inst Stockholm Sweden SE-17177 iol, SE-17177Stockholm, Sweden
Titolo Testata:
JOURNAL OF APPLIED PHYSIOLOGY
fascicolo: 2, volume: 87, anno: 1999,
pagine: 830 - 834
SICI:
8750-7587(199908)87:2<830:SAAOBH>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAROTID BAROREFLEX; SULFUR-HEXAFLUORIDE; DYNAMIC EXERCISE; HUMANS; ANESTHESIA; PRESSURE; NARCOSIS; GASES;
Keywords:
inert-gas narcosis; sedation; orthostatis; blood pressure; chronotropic control;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
27
Recensione:
Indirizzi per estratti:
Indirizzo: Ostlund, A Karolinska Inst, Dept Physiol & Pharmacol, Sect Environm Physiol, SE-17177Stockholm, Sweden Karolinska Inst Stockholm Sweden SE-17177 77Stockholm, Sweden
Citazione:
A. Ostlund e D. Linnarsson, "Slowing and attenuation of baroreflex heart rate control with nitrous oxide in exercising men", J APP PHYSL, 87(2), 1999, pp. 830-834

Abstract

The objective of the present study was to determine whether mild inert-gasnarcosis impairs cardiovascular control mechanisms and contributes to the relative bradycardia that occurs in humans exercising in a hyperbaric environment. Eight healthy subjects were exposed to a normoxic 30% nitrous oxide(N2O) mixture and an air control during dynamic exercise of 100-W intensity. Beat-by-beat heart rate (HR) and invasive arterial blood pressure measurements were made. The sensitivity and the response latency of the arterial-cardiac-chronotropic baroreflex were determined fi om repeated blood pressure and HR transients induced by rapid tilts between the upright and supine posture. A significant increase (37%, P less than or equal to 0.02) of latency in baroreflex responses was found with 30% N2O, as well as a significant depression (16%, P less than or equal to 0.05) in baroreflex sensitivity. There were no differences between air and N2O in steady-state HR. or arterial pressure. We conclude that mild inert-gas narcosis increases the latency and decreases the gain of HR responses to arterial baroreflex stimuli, but this cannot in itself account for the modest, relative bradycardia observed during moderately heavy exercise in a normoxic, hyperbaric environment.

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Documento generato il 27/11/20 alle ore 02:15:44