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Titolo:
Cell adhesion molecules in subretinal fluid: Soluble forms of VCAM-1 (vascular cell adhesion molecule-1) and L-selectin
Autore:
Toker, E; Kazokoglu, H; Sahin, S;
Indirizzi:
Marmara Univ, Fac Med, Dept Ophthalmol, Istanbul, Turkey Marmara Univ Istanbul Turkey Fac Med, Dept Ophthalmol, Istanbul, Turkey Marmara Univ, Fac Med, Dept Immunol, Istanbul, Turkey Marmara Univ Istanbul Turkey v, Fac Med, Dept Immunol, Istanbul, Turkey
Titolo Testata:
INTERNATIONAL OPHTHALMOLOGY
fascicolo: 2, volume: 22, anno: 1998,
pagine: 71 - 76
SICI:
0165-5701(1998)22:2<71:CAMISF>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
PIGMENT EPITHELIAL-CELLS; MASSIVE PERIRETINAL PROLIFERATION; SYSTEMIC LUPUS-ERYTHEMATOSUS; PERI-RETINAL PROLIFERATION; EPIRETINAL MEMBRANES; ENDOTHELIAL-CELLS; RHEUMATOID-ARTHRITIS; CHEMOTACTIC FACTORS; VITREORETINOPATHY; DETACHMENT;
Keywords:
subretinal fluid; rhegmatogenous retinal detachment; proliferative vitreoretinopathy; cell adhesion molecules; vascular cell adhesion molecule-1; L-selectin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Toker, E STFA Bloklari, B-6,Daire 13, TR-81090 Istanbul, Turkey STFA Bloklari B-6,Daire 13 Istanbul Turkey TR-81090 nbul, Turkey
Citazione:
E. Toker et al., "Cell adhesion molecules in subretinal fluid: Soluble forms of VCAM-1 (vascular cell adhesion molecule-1) and L-selectin", INT OPHTHAL, 22(2), 1998, pp. 71-76

Abstract

Purpose: In this study we investigated the presence of soluble VCAM-1 and soluble L-selectin-1 in subretinal fluids (SRF) of patients suffering from rhegmatogenous retinal detachment . Method: Subretinal fluids were collected from drainage sclerotomies during surgery from 27 patients with rhegmatogenous retinal detachment complicated by proliferative vitreoretinopathy (PVR) or uncomplicated retinal detachment. Levels of sVCAM-1 and sL-selectin-1were quantified with ELISA. Results: The mean +/- SEM values of sVCAM-1 and sL-selectin-1 were 222.2 +/- 81 ng/ml and 171.7 +/- 42.1 ng/ml, respectively. The concentrations of sVCAM-1 in patients with Grade C PVR (498.2 +/- 170 3 ng/ml) were significantly different from those with Grade B PVR (45.6+/- 16.5 ng/ml) and uncomplicated retinal detachments (19.4 +/- 12.3 ng/ml). SVCAM-1 concentration in detachments which had been present for more than 8 weeks was 738.8 +/- 431 ng/ml, significantly higher than the levels in detachments of shorter duration (132.4 +/- 47.7 ng/ml). sL-selectin-1 levelin Grade C PVR (291.6 +/- 92.8 ng/ml) was higher than in uncomplicated retinal detachments (72.8 +/- 13.5 ng/ml). Significantly elevated levels of sL-selectin-1 were observed in detachments lasting more than 8 weeks (605 +/-151.1 ng/ml) compared to those of shorter duration (96.3 +/- 13.1 ng/ml). Conclusion: The present study supports growing evidence that these cell adhesion molecules are involved in the inflammatory process during the development and progression of PVR.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 08:20:10