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Titolo:
How to standardize vasomotor tone in serial studies based on quantitation of coronary dimensions?
Autore:
Jost, S; Nolte, CWT; Sturm, M; Hausleiter, J; Hausmann, D;
Indirizzi:
Hannover Med Sch, Dept Cardiol, D-3000 Hannover, Germany Hannover Med SchHannover Germany D-3000 rdiol, D-3000 Hannover, Germany
Titolo Testata:
INTERNATIONAL JOURNAL OF CARDIAC IMAGING
fascicolo: 6, volume: 14, anno: 1998,
pagine: 357 - 372
SICI:
0167-9899(199812)14:6<357:HTSVTI>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOTHELIUM-DEPENDENT DILATION; CONVERTING ENZYME-INHIBITION; ALPHA-ADRENERGIC BLOCKADE; HEALTHY-YOUNG ADULTS; ARTERY BYPASS GRAFTS; COLD PRESSOR TEST; INTRAVASCULAR ULTRASOUND; DYNAMIC EXERCISE; INTRACORONARY NITROGLYCERIN; HEART-DISEASE;
Keywords:
calcium antagonists; coronary vasomotor tone; coronary vasodilation; nitrocompounds; quantitative coronary angiography; standardization;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
105
Recensione:
Indirizzi per estratti:
Indirizzo: Jost, S Theresienklin, Herbert Hellmann Allee 11, D-79189 Bad Krozingen, Germany Theresienklin Herbert Hellmann Allee 11 Bad Krozingen Germany D-79189
Citazione:
S. Jost et al., "How to standardize vasomotor tone in serial studies based on quantitation of coronary dimensions?", INT J CAR I, 14(6), 1998, pp. 357-372

Abstract

In patients with coronary artery disease including those after coronary bypass graft operation and heart transplantation intervention studies based on serial quantitative coronary angiography, in part combined with intravascular ultrasound, are of increasing relevance. Since vasomotor tone of epicardial coronary arteries is influenced by a variety of factors, angiographicfollow-up studies require standardization of coronary tone by induction ofmaximal dilation. We reviewed the effects of the most potent coronary vasodilatory drug groups, calcium antagonists and nitrocompounds, on coronary diameters. Intravenous or intracoronary injections of verapamil, diltiazem, nifedipine, nicardipine, and nisoldipine can cause profound coronary dilation which has been shown to be maximal with verapamil and nisoldipine. Shortcomings of calcium antagonists include short or unknown duration of action after bolus administration, severe drop in blood pressure, and lack of commercial availability of solutions for injection of many substances. Isosorbide dinitrate induces profound coronary dilation; however, after sublingual administration marked blood pressure decrease can occur, and the duration of action and ideal dose of intracoronary isosorbide dinitrate has not been investigated yet. Injections of molsidomine and its active metabolite, SIN-1, cause longlasting, reproducible, maximal coronary dilation, although only after awaiting period of at least 10 minutes; unfortunately, SIN-1 is only commercially available in France. Nitroglycerin induces reproducible maximal coronary dilation and is easy to administer sublingually or as intracoronary bolus injection with rapid onset of action and no major side effects. The short duration of action may require repeated administrations. To date, repeated intracoronary bolus injections of 0.1 mg nitroglycerin every 10 minutes seem to be the optimal known regimen for standardization ofcoronary vasomotor tone in serial angiographic studies. Further investigations in this field with old and new vasodilatory drugs are recommendable.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 22:02:49