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Titolo:
Novel mutation in the ATP-binding site of the MET oncogene tyrosine kinasein a HPRCC family
Autore:
Olivero, M; Valente, G; Bardelli, A; Longati, P; Ferrero, N; Cracco, C; Terrone, C; Rocca-Rossetti, S; Comoglio, PM; Di Renzo, MF;
Indirizzi:
IRCC, Inst Canc Res & Treatment, Canc Genet Lab, I-10060 Turin, Italy IRCC Turin Italy I-10060 Treatment, Canc Genet Lab, I-10060 Turin, Italy INst Canc Res & Treatment, Div Mol Oncol, Turin, Italy INst Canc Res & Treatment Turin Italy ment, Div Mol Oncol, Turin, Italy Univ Turin, Sch Med, Dept Biomed Sci, Turin, Italy Univ Turin Turin Italy iv Turin, Sch Med, Dept Biomed Sci, Turin, Italy Univ Turin, Sch Med, Dept Surg & Med Disciplines, Urol Clin, Turin, Italy Univ Turin Turin Italy Surg & Med Disciplines, Urol Clin, Turin, Italy
Titolo Testata:
INTERNATIONAL JOURNAL OF CANCER
fascicolo: 5, volume: 82, anno: 1999,
pagine: 640 - 643
SICI:
0020-7136(19990827)82:5<640:NMITAS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
RENAL-CELL CARCINOMAS; GROWTH-FACTOR; RECEPTOR; TUMORS; TRANSFORMATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Di Renzo, MF IRCC, Inst Canc Res & Treatment, Canc Genet Lab, SP 142,Km 3-95, I-10060 Turin, Italy IRCC SP 142,Km 3-95 Turin Italy I-10060 I-10060 Turin, Italy
Citazione:
M. Olivero et al., "Novel mutation in the ATP-binding site of the MET oncogene tyrosine kinasein a HPRCC family", INT J CANC, 82(5), 1999, pp. 640-643

Abstract

Germline mutations in the tyrosine-kinase domain of the MET proto-oncogenewere found in patients suffering from the hereditary predisposition to develop multiple papillary renal cell carcinomas (hereditary PRCC, HPRCC), PRCCs are often multiple and bilateral even in patients without a family history. We analyzed the germline of patients carrying multiple or single papillary tumors with and without family history. One patient had a familial cancer and carried a novel (V1110I) germline MET mutation, located in MET gene exon 16, This mis-sense mutation was found in affected members of this patient's family. Interestingly, the V1110I mutation is located in the ATP-binding site of the MET kinase and is homologous to the VI 571 mutation that triggers the sarcomagenic potential of the v-erbB oncogene, The V1 110I mutated MET receptor is an active kinase and transforms NIH-3T3 fibroblasts in the in vitro assays. Patients without familiality did not show germline mutations in the MET kinase domain, showing that multiple and bilateral papillary kidney tumors develop in the absence of these mutations. In conclusion, we describe a new mutation in the MET oncogene kinase domain, associated toHPRCC, affecting an amino-acid residue critical for kinase activation in different oncogenes. Int. J, Cancer 82:640-643, 1999, (C) 1990 Wiley-Liss. Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 00:11:25