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Titolo:
EVIDENCE FOR THE PROMOTION OF POSITIVE SELECTION OF THYMOCYTES BY AH RECEPTOR AGONIST 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN
Autore:
KREMER J; LAI ZW; ESSER C;
Indirizzi:
UNIV DUSSELDORF,MED INST ENVIRONM HYG,DIV IMMUNOL,AUF HENNEKAMP 50 D-40225 DUSSELDORF GERMANY UNIV DUSSELDORF,MED INST ENVIRONM HYG,DIV IMMUNOL D-40225 DUSSELDORF GERMANY
Titolo Testata:
European journal of pharmacology. Environmental toxicology and pharmacology section
fascicolo: 4, volume: 293, anno: 1995,
pagine: 413 - 427
SICI:
0926-6917(1995)293:4<413:EFTPOP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEGATIVE SELECTION; LYMPHOCYTES-T; EXPRESSION; TCDD; MATURATION; TOXICITY; DIOXIN; MECHANISM; SUPERANTIGENS; STIMULATION;
Keywords:
2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN; THYMOCYTE SELECTION; ARYLHYDROCARBON RECEPTOR; APOPTOSIS; BCL-2; THYMUS ORGAN CULTURE, MOUSE FETAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
J. Kremer et al., "EVIDENCE FOR THE PROMOTION OF POSITIVE SELECTION OF THYMOCYTES BY AH RECEPTOR AGONIST 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN", European journal of pharmacology. Environmental toxicology and pharmacology section, 293(4), 1995, pp. 413-427

Abstract

2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a ligand for the arylhydrocarbon receptor (Ah receptor), abundant in the murine thymus. In the thymus immunocompetent T cells develop. Upon exposure of murine fetal thymi in organ cultures to TCDD the distribution of mature and immature thymocytes is skewed towards apparently mature, prospective cytotoxic cells of the CD4(-)CD8(+)T cell receptor(+) phenotype. The normally abundant CD4(+)CD8(+) cells are decreased. Proliferation of the mostimmature thymocyte subpopulations is inhibited and maturation of thymocytes appears accelerated by TCDD. Eventually the thymocyte number issignificantly decreased. Selective treatment of stroma cells showed them to be the primary target cells of TCDD action. Thymus stroma playsa pivotal role in thymocyte maturation and is indispensable for the selection of thymocytes bearing T cell receptors specific for foreign antigen in the context of self. We tested whether the effects of TCDD on thymocyte differentiation and maturation has further consequences for the selection processes by analysing (a) the repertoire of V-beta genes used as a measure for negative selection and (b) the expression ofCD69 and bcl-2 by thymocytes as a parameter for positive selection. Our data indicate that TCDD does not cause gross disturbance of negative selection but provide evidence for more cells auditioning for positive selection by TCDD exposure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 07:05:33