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Titolo:
Comparison of different methods for dead space measurements in ventilated newborns using CO2-volume plot
Autore:
Wenzel, U; Wauer, RR; Schmalisch, G;
Indirizzi:
Humboldt Univ, Clin Neonatol, Charite Hosp, D-10098 Berlin, Germany Humboldt Univ Berlin Germany D-10098 arite Hosp, D-10098 Berlin, Germany
Titolo Testata:
INTENSIVE CARE MEDICINE
fascicolo: 7, volume: 25, anno: 1999,
pagine: 705 - 713
SICI:
0342-4642(199907)25:7<705:CODMFD>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY DEADSPACE MEASUREMENTS; FUNCTIONAL RESIDUAL CAPACITY; SINGLE BREATH TEST; CARBON-DIOXIDE; INFANTS; CHILDREN; CO2;
Keywords:
respiratory dead space; carbon dioxide; lung function testing; mechanical ventilation; newborn; single breath test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
41
Recensione:
Indirizzi per estratti:
Indirizzo: Wauer, RR Humboldt Univ, Clin Neonatol, Charite Hosp, Schumannstr 20-21, D-10098 Berlin, Germany Humboldt Univ Schumannstr 20-21 Berlin Germany D-10098 Germany
Citazione:
U. Wenzel et al., "Comparison of different methods for dead space measurements in ventilated newborns using CO2-volume plot", INTEN CAR M, 25(7), 1999, pp. 705-713

Abstract

Objective: The aim of the study was to test the applicability of Ventrak 1550/Capnogard 1265 (V-C) for respiratory dead space (VD) measurement and todetermine anatomic (V-Dana), physiologic (V-Dphys), and alveolar dead spaces (V-Dalv) in ventilated neonates. Design: Prospective study. Setting: Neonatal intensive care unit. Patients: 33 investigations in 22 ventilated neonates; median gestational age 34.5 weeks (range 27-41), median birthweight 2658 g (range 790-3940). Method: The single-breath CO2 test (SBT-CO2) and transcutaneous partial pressure of carbon dioxide (PCO2) were recorded simultaneously and VD was determined (1) automatically (V-C software), (2) by interactive analysis of the PCO2 volume plot, and (3) manually by Bohr/Enghoff equations using data obtained by V-C. Results: VD measurements were possible in all cases by method 3 but not possible by methods 1 and 2 in 22 of 33 investigations (67 %), especially in preterm neonates, because of disturbed signals. V-Dana/kg (1.6 +/- 0.6 ml/kg, mean +/- SD), V-Dana/tidal volume (V-T) (0.36 +/- 0.09) were lower compared to published data in spontaneously breathing infants, whereas V-Dphys/kg (2.3 +/- 0.9 ml/kg) and V-Dphys/VT (0.50 +/- 0.12) are comparable to dataobtained from the literature. Five minutes after insertion of the sensor (dead space 2.6 mi) into the ventilatory circuit, the transcutaneous PCO2 rose above baseline for 3.2% (patients > 2500 g) and 5.7% (patients < 2500 g). The time necessary for one analysis was 50-60 min. Conclusion: In ventilated newborns, dead space measurements were possible only in one-third by SBT-CO2, but in all cases by Bohr/Enghoff equations. Improved software could further reduce the time needed for one analysis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/04/20 alle ore 02:11:27