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Titolo:
Testicular sperm retrieval and cryopreservation prior to initiating ovarian stimulation as the first line approach in patients with non-obstructive azoospermia
Autore:
Ben-Yosef, D; Yogev, L; Hauser, R; Yavetz, H; Azem, F; Yovel, I; Lessing, JB; Amit, A;
Indirizzi:
Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Lis Latern Hosp,Sara Racine IVF Unit, IL-64239 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-64239 F Unit, IL-64239 Tel Aviv, Israel Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Lis Latern Hosp,Inst Study Fertil, IL-64239 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-64239 Fertil, IL-64239 Tel Aviv, Israel
Titolo Testata:
HUMAN REPRODUCTION
fascicolo: 7, volume: 14, anno: 1999,
pagine: 1794 - 1801
SICI:
0268-1161(199907)14:7<1794:TSRACP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NONOBSTRUCTIVE AZOOSPERMIA; INTRACYTOPLASMIC INJECTION; EPIDIDYMAL SPERMATOZOA; FERTILIZING ABILITY; IMPLANTATION RATES; PREGNANCY; EXTRACTION; BIOPSY; FRESH; MEN;
Keywords:
non-obstructive azoospermia; spermatozoa; testicular sperm cryopreservation; testicular sperm extraction;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Ben-Yosef, D Tel Aviv Univ, Sackler Fac Med, Tel Aviv Sourasky Med Ctr, Lis Latern Hosp,Sara Racine IVF Unit, 6 Weizmann St, IL-64239 Tel Aviv, Israel Tel Aviv Univ 6 Weizmann St Tel Aviv Israel IL-64239 Israel
Citazione:
D. Ben-Yosef et al., "Testicular sperm retrieval and cryopreservation prior to initiating ovarian stimulation as the first line approach in patients with non-obstructive azoospermia", HUM REPR, 14(7), 1999, pp. 1794-1801

Abstract

The potency for fertilization and successful implantation was compared between fresh and cryopreserved testicular spermatozoa obtained from the same patient with nonobstructive azoospermia, Spermatozoa cryopreserved at the outset were also evaluated. Non-obstructive azoospermic men(n = 55) underwent testicular sperm extraction (TESE); mature spermatozoa were found in 33 (60%) of them. Of 57 intracytoplasmic sperm injection (ICSI) cycles in 25 patients, 15 used fresh spermatozoa (14 patients, group 1), 24 used the excess spermatozoa cryopreserved after 'fresh' ICSI (11 couples who did not conceive in the 'fresh' cycle, group 2) and 18 cycles used cryopreserved spermatozoa at the outset (11 other patients, group 3), Fertilization, cleavage, embryo quality, implantation and take home baby rates were not significantly different in groups 1 and 2, and 6/14 couples ultimately had healthy babies (42.8% cumulative take home baby rate per TESE). In group 3, neither thefertilization rate, embryo development, pregnancy nor implantation rates per embryo transfer were significantly different from groups 1 and 2, The cumulative delivery and ongoing pregnancy rate in this group was 36.4%. Cryopreservation did not impair the availability of motile spermatozoa for ICSI,When immotile spermatozoa were injected, however, fertilization rate decreased dramatically. Since criteria for predicting the presence of spermatozoa in the testicular tissue of patients with non-obstructive azoospermia areinadequate, it is suggested that TESE be performed prior to initiating ovarian stimulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 02:24:50