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Titolo:
Human neuroimaging of acute and chronic marijuana use: Implications for frontocerebellar dysfunction
Autore:
Loeber, RT; Yurgelun-Todd, DA;
Indirizzi:
McLean Hosp, Brain Imaging Ctr, Dept Psychiat, Belmont, MA 02478 USA McLean Hosp Belmont MA USA 02478 tr, Dept Psychiat, Belmont, MA 02478 USA Boston Univ, Sch Med, Program Behav Neurosci, Boston, MA 02118 USA Boston Univ Boston MA USA 02118 gram Behav Neurosci, Boston, MA 02118 USA
Titolo Testata:
HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL
fascicolo: 5, volume: 14, anno: 1999,
pagine: 291 - 304
SICI:
0885-6222(199907)14:5<291:HNOAAC>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; CHRONIC DELTA-9-TETRAHYDROCANNABINOL THC; POSITRON EMISSION TOMOGRAPHY; RAT-BRAIN REGIONS; CANNABINOID RECEPTOR; CEREBELLAR CONTRIBUTION; DOPAMINE NEURONS; CHRONIC EXPOSURE; MESSENGER-RNA; RHESUS-MONKEY;
Keywords:
marijuana; positron emission tomography; magnetic resonance imaging; dopamine; frontal lobes; cerebellum;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
72
Recensione:
Indirizzi per estratti:
Indirizzo: Yurgelun-Todd, DA McLean Hosp, Brain Imaging Ctr, Dept Psychiat, 115 Mill St, Belmont, MA 02478 USA McLean Hosp 115 Mill St Belmont MA USA 02478 A 02478 USA
Citazione:
R.T. Loeber e D.A. Yurgelun-Todd, "Human neuroimaging of acute and chronic marijuana use: Implications for frontocerebellar dysfunction", HUM PSYCHOP, 14(5), 1999, pp. 291-304

Abstract

The effects of cannabis use on the human brain are not well understood. Recently neuroimaging research has begun to address the question of metabolicchanges secondary to (1) long-term chronic cannabis use, and (2) acute intoxication due to cannabis smoke or injection of delta-9-tetrahydrocannabinol (Delta(9)-THC) solution. A comprehensive review of the neuroimaging literature was performed. To further interpret and understand this research, literature addressing animal receptor and neurochemical models were also surveyed. Neuroimaging findings have concluded that abstinence from smoking results in depressed cerebral metabolism in chronic users, while acute exposurereverses this condition, producing higher cerebral blood flow in chronic users compared to controls. These changes are hypothesized to be associated with alterations of cannabinoid receptors secondary to chronic exposure. Findings from animal models are consistent with the proposition that adaptation to chronic exposure results in adjustment of normal neurotransmitter levels. The frontopontocerebellar network is implicated as a site sensitive tocannabinoid-induced alterations in the levels of dopaminergic activity derived through the medial forebrain bundle, which projects from the ventral tegmental area. This network is involved in the modulation of a range of human behavior that is clearly altered by use of cannabis. The combined neuroimaging and animal data suggest that metabolism of component regions of the frontopontocerebellar network are altered by acute and chronic exposure to cannabis through modulation of both the cannabinoid and the dopamine system. Copyright (C) 1999 John Wiley & Sons, Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:49:09