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Titolo:
Positron emission tomography of cortical centers of tinnitus
Autore:
Mirz, F; Pedersen, CB; Ishizu, K; Johannsen, P; Ovesen, T; Stodkilde-Jorgensen, H; Gjedde, A;
Indirizzi:
Aarhus Univ Hosp, Dept Otorhinolaryngol, DK-8000 Aarhus C, Denmark Aarhus Univ Hosp Aarhus Denmark C inolaryngol, DK-8000 Aarhus C, Denmark Aarhus Univ, PET Ctr, DK-8000 Aarhus, Denmark Aarhus Univ Aarhus DenmarkDK-8000 niv, PET Ctr, DK-8000 Aarhus, Denmark Aarhus Univ Hosp, MR Res Ctr, DK-8000 Aarhus, Denmark Aarhus Univ Hosp Aarhus Denmark DK-8000 Res Ctr, DK-8000 Aarhus, Denmark
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 134, anno: 1999,
pagine: 133 - 144
SICI:
0378-5955(199908)134:1-2<133:PETOCC>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACOUSTIC NEUROMA SURGERY; AUDITORY-VERBAL MEMORY; BRAIN-STEM; PREFRONTAL CORTEX; FUNCTIONAL NEUROANATOMY; OTOACOUSTIC EMISSIONS; SUSTAINED ATTENTION; EVOKED RESPONSES; EPISODIC MEMORY; HALLUCINATIONS;
Keywords:
tinnitus; positron emission tomography; functional brain imaging;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
103
Recensione:
Indirizzi per estratti:
Indirizzo: Mirz, F Aarhus Univ Hosp, Dept Otorhinolaryngol, Norrebrogade 44, DK-8000 Aarhus C, Denmark Aarhus Univ Hosp Norrebrogade 44 Aarhus Denmark C rhus C, Denmark
Citazione:
F. Mirz et al., "Positron emission tomography of cortical centers of tinnitus", HEARING RES, 134(1-2), 1999, pp. 133-144

Abstract

Tinnitus is associated with a wide variety of disorders in the auditory system. Whether generated peripherally or centrally, tinnitus is believed to be associated with activity in specific cortical regions. The present studytested the hypothesis that these cortical centers subserve the generation,perception and processing of the tinnitus stimulus and that these processes are suppressed by lidocaine and masking. Positron emission tomography wasused to map the tinnitus-specific central activity. By subtracting positron emission tomography images of regional cerebral blood flow distribution obtained during suppression of the tinnitus from positron emission tomography images obtained during the habitual tinnitus sensation, we were able to identify brain areas concerned with the cerebral representation of tinnitus. Increased neuronal activity caused by tinnitus occurred predominantly in the right hemisphere with significant foci in the middle frontal and middle temporal gyri, in addition to lateral and mesial posterior sites. The results are consistent with the hypothesis that the sensation of tinnitus is associated with activity in cortical regions functionally linked to subserve attention, emotion and memory. For the first time, the functional anatomy ofconditions with and without the habitual tinnitus sensation was obtained and compared in the same subjects. (C) 1999 Elsevier Science B.V. All rightsreserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 14:33:14