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Titolo:
Olivocochlear neurons in the chinchilla: a retrograde fluorescent labelling study
Autore:
Azeredo, WJ; Kliment, ML; Morley, BJ; Relkin, E; Slepecky, NB; Sterns, A; Warr, WB; Weekly, JM; Woods, CI;
Indirizzi:
SUNY Hlth Sci Ctr, Dept Otolaryngol, Syracuse, NY 13210 USA SUNY Hlth Sci Ctr Syracuse NY USA 13210 olaryngol, Syracuse, NY 13210 USA Syracuse Univ, Inst Sensory Res, Dept Bioengn & Neurosci, Syracuse, NY USASyracuse Univ Syracuse NY USA Dept Bioengn & Neurosci, Syracuse, NY USA Boys Town Natl Res Hosp, Omaha, NE 68131 USA Boys Town Natl Res Hosp Omaha NE USA 68131 Res Hosp, Omaha, NE 68131 USA
Titolo Testata:
HEARING RESEARCH
fascicolo: 1-2, volume: 134, anno: 1999,
pagine: 57 - 70
SICI:
0378-5955(199908)134:1-2<57:ONITCA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
TENSOR TYMPANI MUSCLE; CONTRALATERAL SOUND STIMULATION; COMPOUND ACTION-POTENTIALS; SUPERIOR OLIVARY COMPLEX; COCHLEAR EFFERENT SYSTEM; GUINEA-PIG COCHLEA; BRAIN-STEM; HORSERADISH-PEROXIDASE; ACOUSTIC STIMULATION; SQUIRREL-MONKEY;
Keywords:
olivocochlear bundle; olivocochlear neuron; superior olivary complex; efferent innervation of the cochlea; chinchilla;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
62
Recensione:
Indirizzi per estratti:
Indirizzo: Woods, CI SUNY Hlth Sci Ctr, Dept Otolaryngol, 750 E Adams St, Syracuse, NY 13210 USA SUNY Hlth Sci Ctr 750 E Adams St Syracuse NY USA 13210 13210 USA
Citazione:
W.J. Azeredo et al., "Olivocochlear neurons in the chinchilla: a retrograde fluorescent labelling study", HEARING RES, 134(1-2), 1999, pp. 57-70

Abstract

Although the chinchilla is widely used as a model for auditory research, little is known about the distribution and morphology of its olivocochlear neurons. Here, we report on the olivocochlear neurons projecting to one cochlea, as determined by single and double retrograde fluorescent tracer techniques. 10 adult chinchillas were anesthetized and given either unilateral or bilateral injections of a fluorescent tracer (either Fluoro-Gold or Fast Blue) into scala tympani or as a control, a unilateral injection into the middle ear cavity. The results indicate that there are similarities as well as significant differences between the chinchilla and other species of rodents in the distributions of their olivocochlear neurons. Based on three well-labelled cases, there was a mean total of 1168 olivocochlear neurons in the chinchilla. Of these, the majority (mean 787) were small, lateral olivocochlear neurons found almost exclusively within the ipsilateral lateral superior olivary nucleus. The next largest group consisted of a mean of 280 medial olivocochlear neurons virtually all of which were located in the dorsomedial peri-olivary nucleus. Chinchilla medial olivocochlear neurons were more predominantly crossed in their projections (4:1) than in any known species. The smallest group of olivocochlear neurons (mean 101) consisted of larger lateral olivocochlear neurons (shell neurons) which were located on the margins of the superior olivary nucleus and which projected mainly (2.2:1) ipsilaterally. Double retrograde labelling was observed only in medial olivocochlear neurons and occurred in only 1-2% of these cells. The results confirm previous findings which indicated a relative paucity of fibers belonging to the uncrossed as compared to the crossed olivocochlear bundle. This, together with the strong apical bias of the uncrossed projection reportedpreviously, offers possible explanations for the apparent absence of efferent-mediated suppressive effects of contralateral acoustic stimulation in this species. Regarding the lateral olivocochlear system, the chinchilla is shown to possess both intrinsic and shell neurons, as in the rat. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/08/20 alle ore 06:23:49