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Titolo:
Reactive oxygen metabolites, antioxidants and head and neck cancer
Autore:
Seidman, MD; Quirk, WS; Shirwany, NA;
Indirizzi:
Henry Ford Hosp, Dept Otolaryngol Head & Neck Surg, W Bloomfield, MI 48323USA Henry Ford Hosp W Bloomfield MI USA 48323 Surg, W Bloomfield, MI 48323USA Mankato State Univ, Dept Commun Disorders, Off Grad Studies, Mankato, MN 56001 USA Mankato State Univ Mankato MN USA 56001 ad Studies, Mankato, MN 56001 USA
Titolo Testata:
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
fascicolo: 5, volume: 21, anno: 1999,
pagine: 467 - 479
SICI:
1043-3074(199908)21:5<467:ROMAAH>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTERCELLULAR-ADHESION MOLECULE-1; INDUCED COCHLEAR DAMAGE; CU/ZN-SUPEROXIDE-DISMUTASE; LIPID-PEROXIDATION DAMAGE; HUMAN-MALIGNANT MELANOMA; DNA-REPAIR CAPACITY; AGE-RELATED-CHANGES; VITAMIN-E; GLUTATHIONE-PEROXIDASE; GENE-EXPRESSION;
Keywords:
reactive oxygen metabolites; head and neck cancer; antioxidants;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
179
Recensione:
Indirizzi per estratti:
Indirizzo: Seidman, MD Henry Ford Hosp, Dept Otolaryngol Head & Neck Surg, 6777 W Maple Rd, W Bloomfield, MI 48323 USA Henry Ford Hosp 6777 W Maple Rd W Bloomfield MI USA 48323 USA
Citazione:
M.D. Seidman et al., "Reactive oxygen metabolites, antioxidants and head and neck cancer", HEAD NECK, 21(5), 1999, pp. 467-479

Abstract

This manuscript will review the probable role of reactive oxygen metabolites (ROM) in the etiopathogenesis of head and neck cancer (HNC). Cancer is aheterogeneous disorder with multiple etiologies including somatic and germ-line mutations, cellular homeostatic disturbances, and environmental triggers. Certain etiologies are characteristic of HNC and include infectious agents such as the Epstein-Barr virus, the use of tobacco, and consumption ofalcohol. A large body of evidence implicates ROM in tumor formation and promotion. ROM species are formed in the process of cellular respiration, specificallyduring oxidative phosphorylation. These ubiquitous molecules are highly toxic in the cellular environment. Of the many effects of ROM, especially important are their effect on DNA. Specifically, ROM cause a variety of DNA damage, including insertions, point mutations, and deletions. Thus, it is hypothesized that ROM may be critically involved in the etiology of malignant disease through their possible impact on protooncogenes and tumor suppressor genes. Additionally, empirical evidence suggests that ROM may also affectthe balance between apoptosis and cellular proliferation. If apoptotic mechanisms are overwhelmed, uncontrolled cellular proliferation may follow, potentially leading to tumor formation. Thus, this manuscript will criticallyreview the evidence that supports the role of ROM in tumorigenesis. ROM scavengers and blockers have shown both in vivo and in vitro effects of attenuating the toxicity of ROM. Such compounds include the antioxidant vitamins (A, C, and E), nutrient trace elements (selenium), enzymes (superoxide dismutase, glutathione peroxidase, and catalase), hormones (melatonin),and a host of natural and synthetic compounds (lazaroids, allopurinol, gingko extract). Thus, this paper will also review the possible benefit derived from the use of such scavengers/blockers in the prevention of HNC. (C) 1999 John Wiley & Sons, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 12:10:31