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Titolo:
Aspects of connectivity in schizophrenia: Introduction
Autore:
Erkwoh, R; Sabri, O; Willmes, K; Steinmeyer, EM; Bull, U; Sass, H;
Indirizzi:
Rhein Westfal TH Aachen, Klin Psychiat & Psychotherapie, D-52074 Aachen, Germany Rhein Westfal TH Aachen Aachen Germany D-52074 , D-52074 Aachen, Germany Rhein Westfal TH Aachen, Klin Nukl Med, D-52074 Aachen, Germany Rhein Westfal TH Aachen Aachen Germany D-52074 , D-52074 Aachen, Germany Rhein Westfal TH Aachen, Neurol Klin, D-52074 Aachen, Germany Rhein Westfal TH Aachen Aachen Germany D-52074 , D-52074 Aachen, Germany Univ Cologne, Klin Psychiat & Psychotherapie, D-5000 Cologne 41, Germany Univ Cologne Cologne Germany 41 ychotherapie, D-5000 Cologne 41, Germany
Titolo Testata:
FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE
fascicolo: 7, volume: 67, anno: 1999,
pagine: 318 - 326
SICI:
0720-4299(199907)67:7<318:AOCISI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
GER
Soggetto:
CEREBRAL BLOOD-FLOW; DORSOLATERAL PREFRONTAL CORTEX; POSITRON EMISSION TOMOGRAPHY; NEVER-TREATED SCHIZOPHRENICS; NEUROLEPTIC-NAIVE PATIENTS; PHYSIOLOGIC DYSFUNCTION; FUNCTIONAL CONNECTIVITY; COMPUTED-TOMOGRAPHY; POSITIVE SYMPTOMS; ATTENTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
68
Recensione:
Indirizzi per estratti:
Indirizzo: Erkwoh, R Rhein Westfal TH Aachen, Klin Psychiat & Psychotherapie, Pauwelsstr 30, D-52074 Aachen, Germany Rhein Westfal TH Aachen Pauwelsstr 30 Aachen Germany D-52074 ny
Citazione:
R. Erkwoh et al., "Aspects of connectivity in schizophrenia: Introduction", F NEUR PSYC, 67(7), 1999, pp. 318-326

Abstract

The hypothesis of prefrontal-temporolimbic disconnectivity, considered to be relevant to the pathogenesis of schizophrenia, has been tested in 29 drug-naive schizophrenic patients, comparing the active with the remitted state. Method: A pre-post treatment design was applied to 29 drug-naive schizophrenic inpatients, 18 male, mean age 32 years, 11 female, mean age 32 years, mean duration of illness 29 months. Psychopathological symptoms were assessed using PANSS, regional cerebral blood (rCBF) was measured by HMPAO-SPECT. RCBF values were calculated for 21 regions of interest after normalization to cerebellum, and plotted by Euklidean diagrams using the ordinal, nonmetric, multidimensional scaling method. These diagrams represent similaritycorrelations visualized as spatial distances. High correlation levels as indicated by small Euklidean distances have been interpreted as functional connectivity. Results: In active schizophrenia, functional disconnectivity was observed between prefrontal and temporal cortex. After remission, connectivity was improved between temporolimbic and frontal cortex. Conclusion: Comparing active with remitted schizophrenia, a frontotemporal disconnectivity appears. Temporolimbic as well as frontolimbic connections restitute parallel to psychopathological improvement.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 07:36:47