Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of conditioned fear stress on serotonin neurotransmission and freezing behavior in rats
Autore:
Hashimoto, S; Inoue, T; Koyama, T;
Indirizzi:
Hokkaido Univ, Sch Med, Dept Psychiat, Kita Ku, Sapporo, Hokkaido 0608638,Japan Hokkaido Univ Sapporo Hokkaido Japan 0608638 poro, Hokkaido 0608638,Japan
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 1, volume: 378, anno: 1999,
pagine: 23 - 30
SICI:
0014-2999(19990728)378:1<23:EOCFSO>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
GENERALIZED ANXIETY DISORDER; DOUBLE-BLIND; SOCIAL PHOBIA; EXTRACELLULAR 5-HYDROXYTRYPTAMINE; RECEPTOR ANTAGONISTS; REUPTAKE INHIBITORS; MULTICENTER TRIAL; PANIC DISORDER; CITALOPRAM; 5-HT;
Keywords:
5-HT (hydroxytryptamine, serotonin); conditioned fear stress; freezing behavior; microdialysis, in vivo; medial prefrontal cortex; citalopram;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Hashimoto, S Hokkaido Univ, Sch Med, Dept Psychiat, Kita Ku, North 15,West7, Sapporo, Hokkaido 0608638, Japan Hokkaido Univ North 15,West 7 Sapporo Hokkaido Japan 0608638
Citazione:
S. Hashimoto et al., "Effects of conditioned fear stress on serotonin neurotransmission and freezing behavior in rats", EUR J PHARM, 378(1), 1999, pp. 23-30

Abstract

In an attempt to clarify the role of the brain serotonergic system in the psychopathology of anxiety, we examined the effect of a psychological stress, conditioned fear stress, on extracellular serotonin (5-hydroxytryptamine, 5-HT) concentrations in the rat medial prefrontal cortex using the methodof in vivo microdialysis, while simultaneously observing conditioned fear stress-induced freezing behavior, an index of anxiety. Conditioned fear stress increased extracellular 5-HT levels in the medial prefrontal cortex, and this 5-HT level increase was followed by a resolution of the freezing behavior. A dose of 10 mg/kg of a selective 5-HT reuptake inhibitor, citalopram, administered 60 min before exposure to conditioned fear stress increasedextracellular 5-HT concentrations immediately and potently, reducing freezing behavior. These findings strongly suggest that facilitation of brain 5-HT neurotransmission decreases anxiety, which is in agreement with the clinical reports that selective 5-HT reuptake inhibitors are effective in the treatment of anxiety disorders. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 18:32:40