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Titolo:
Insulin stimulates triacylglycerol secretion by perfused livers from fed rats but inhibits it in livers from fasted or insulin-deficient rats - Implications for the relationship between hyperinsulinaemia and hypertriglyceridaemia
Autore:
Zammit, VA; Lankester, DJ; Brown, AM; Park, BS;
Indirizzi:
Hannah Res Inst, Ayr KA6 5HL, Scotland Hannah Res Inst Ayr Scotland KA6 5HL nah Res Inst, Ayr KA6 5HL, Scotland
Titolo Testata:
EUROPEAN JOURNAL OF BIOCHEMISTRY
fascicolo: 3, volume: 263, anno: 1999,
pagine: 859 - 864
SICI:
0014-2956(199908)263:3<859:ISTSBP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-DENSITY LIPOPROTEIN; FREE FATTY-ACIDS; CARNITINE PALMITOYLTRANSFERASE; CULTURED-HEPATOCYTES; REMNANT LIPOPROTEINS; B PRODUCTION; TRIGLYCERIDE; METABOLISM; DISEASE; KETOGENESIS;
Keywords:
coronary artery disease; diabetes; etherosclerosis; fasting; hypertiglyceridemia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Zammit, VA Hannah Res Inst, Ayr KA6 5HL, Scotland Hannah Res Inst Ayr Scotland KA6 5HL t, Ayr KA6 5HL, Scotland
Citazione:
V.A. Zammit et al., "Insulin stimulates triacylglycerol secretion by perfused livers from fed rats but inhibits it in livers from fasted or insulin-deficient rats - Implications for the relationship between hyperinsulinaemia and hypertriglyceridaemia", EUR J BIOCH, 263(3), 1999, pp. 859-864

Abstract

We determined whether the direction of the acute effect of insulin on hepatic triacylglycerol secretion is dependent on the prior physiological stateor on the in vitro experimental system used. The effect of insulin on triacylglycerol secretion was studied using perfused livers isolated from rats under three metabolic conditions: fed normo-insulinaemic, 24-h fasted and fed, streptozotocin-diabetic (insulin-deficient). Insulin acutely activated triacylglycerol secretion (by 43%) in organs from fed, normo-insulinaemic animals, whereas it inhibited triacylglycerol secretion in livers isolated from fasted or insulin-deficient rats (by 30 and 33%, respectively). By contrast, in 24-h-cultured hepatocytes insulin invariably acutely inhibited triacylglycerol secretion irrespective of the metabolic state of the donor animals. It is concluded that the use of perfused livers enables the observation of a switch in the direction of insulin action on hepatic triacylglycerol secretion from stimulatory, in the normo-insulinaemic state, to inhibitory in the fasting or insulin-deficient state. The possible implications of this switch for the relationship between hyperinsulinaemia, increased hepatic very-low-density lipoprotein-triacylglycerol secretion and hypertriglyceridaemia observed in vivo are discussed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 07:56:19