Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Fluconazole versus amphotericin B for the prevention of fungal infection in neutropenic patients with hematologic malignancy
Autore:
Takatsuka, H; Takemoto, Y; Okamoto, T; Fujimori, Y; Tamura, S; Wada, H; Okada, M; Kanamaru, A; Kakishita, E;
Indirizzi:
Hyogo Coll Med, Dept Internal Med 2, Nishinomiya, Hyogo 6638501, Japan Hyogo Coll Med Nishinomiya Hyogo Japan 6638501 miya, Hyogo 6638501, Japan Kinki Univ, Sch Med, Dept Internal Med 3, Osaka 589, Japan Kinki Univ Osaka Japan 589 ch Med, Dept Internal Med 3, Osaka 589, Japan
Titolo Testata:
DRUGS UNDER EXPERIMENTAL AND CLINICAL RESEARCH
fascicolo: 4, volume: 25, anno: 1999,
pagine: 193 - 200
SICI:
0378-6501(1999)25:4<193:FVABFT>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; ACUTE-LEUKEMIA; ANTIFUNGAL PROPHYLAXIS; CANCER-PATIENTS; THERAPY; TRIAL; GRANULOCYTOPENIA; KETOCONAZOLE; FEVER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Takatsuka, H Hyogo Coll Med, Dept Internal Med 2, 1-1 Mukogawa Cho, Nishinomiya, Hyogo 6638501, Japan Hyogo Coll Med 1-1 Mukogawa Cho Nishinomiya Hyogo Japan 6638501
Citazione:
H. Takatsuka et al., "Fluconazole versus amphotericin B for the prevention of fungal infection in neutropenic patients with hematologic malignancy", DRUG EXP CL, 25(4), 1999, pp. 193-200

Abstract

Effective prophylaxis against fungal infection is important in neutropenicpatients with hematologic malignancies, but the best method remains unclear: We investigated the effectiveness of fungal prophy laxis with amphotericin B or fluconazole. We reviewed the data on fungal isolates, plasma (1-->3)- beta-D glucan (beta-D glucan) levels, febrile periods (the number of days with an axillary temperature >38 degrees C), and the duration of an axillary temperature >38 degrees C when the neutrophil count was <500/mu l. Of the 124 patients studied, 57 had acute myelogenous leukemia, 19 had acute lymphoblastic leukemia, 18 had non-Hodgkin's lymphoma, six had chronic myeloid leukemia, three had adult T-cell leukemia, and five had chronic lymphocytic leukemia. There were no significant differences in clinical characteristics between the 70 patients treated with amphotericin B and the 54 patientsgiven fluconazole. There was a significant decrease of fungal isolates (chi(2)-test, p <0.001), the plasma beta-D glucan level (Wilcoxon test, p =0.0001), and the febrile period (t-test, p <0.05) in the patients given fluconazole compared with those given amphotericin B. In neutropenic patients with hematologic malignancies, prophylaxis with fluconazole significantly decreased fungal isolation and other indicators of fungal infection when compared with amphotericin B. Fluconazole may therefore be more effective for fungal prophylaxis in these patients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 15:32:01