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Titolo:
Depressive symptomatology and cocaine-induced pituitary-adrenal axis activation in individuals with cocaine dependence
Autore:
Elman, I; Breiter, HC; Gollub, RL; Krause, S; Kantor, HL; Baumgartner, WA; Gastfriend, DR; Rosen, BR;
Indirizzi:
Massachusetts Gen Hosp, Dept Psychiat, Addict Serv, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 ict Serv, Boston, MA 02114 USA Harvard Univ, Sch Med, Boston, MA 02114 USA Harvard Univ Boston MA USA 02114 vard Univ, Sch Med, Boston, MA 02114 USA Massachusetts Gen Hosp, Dept Radiol, Nucl Magnet Resonance Ctr, Boston, MA02114 USA Massachusetts Gen Hosp Boston MA USA 02114 nance Ctr, Boston, MA02114 USA Massachusetts Gen Hosp, Dept Cardiol, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Cardiol, Boston, MA 02114 USA W Los Angeles Vet Adm Med Ctr, Los Angeles, CA USA W Los Angeles Vet Adm Med Ctr Los Angeles CA USA tr, Los Angeles, CA USA Univ So Calif, Sch Pharm, Los Angeles, CA USA Univ So Calif Los Angeles CA USA o Calif, Sch Pharm, Los Angeles, CA USA
Titolo Testata:
DRUG AND ALCOHOL DEPENDENCE
fascicolo: 1, volume: 56, anno: 1999,
pagine: 39 - 45
SICI:
0376-8716(19990802)56:1<39:DSACPA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING HORMONE; POSITRON EMISSION TOMOGRAPHY; BETA-ENDORPHIN LEVELS; MAJOR DEPRESSION; NEUROENDOCRINE FUNCTION; STIMULATION TEST; ACTH-SECRETION; PANIC DISORDER; CORTISOL; ABUSE;
Keywords:
cocaine; hypothalamic-pituitary-adrenal axis; clinical pharmacology; depression; comorbidity; endocrinology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Elman, I Massachusetts Gen Hosp, Dept Psychiat, Addict Serv, 15 Parkman StWACC-812, Boston, MA 02114 USA Massachusetts Gen Hosp 15 Parkman St WACC-812 Boston MA USA 02114
Citazione:
I. Elman et al., "Depressive symptomatology and cocaine-induced pituitary-adrenal axis activation in individuals with cocaine dependence", DRUG AL DEP, 56(1), 1999, pp. 39-45

Abstract

The hypothalamic-pituitary-adrenal (HPA) axis plays a role in cocaine dependence and major depressive disorder. The authors examined the correlation between baseline depressive symptomatology and pituitary-adrenal axis activation induced by acute cocaine challenge. Twelve patients with cocaine dependence were administered an iv bolus of cocaine (0.6 mg/kg) and their plasma was assayed for levels of adrenocorticotropic hormone (ACTH) and cortisol. Depressive symptomatology was assessed with total Hamilton rating scale for depression (HRSD) scores and its vegetative and cognitive superfactors. Cocaine produced a mean increase from baseline of 261% for ACTH and 73% forcortisol plasma levels. Changes in ACTH (r = 0.69) and cortisol (r = 0.59)were positively and significantly correlated with total HRSD scores and its vegetative, but not cognitive, factor symptom cluster. These results suggest that the HPA axis may be involved in affective disturbances associated with the use of cocaine. Implications of these data for the pathophysiologyof cocaine dependence are discussed. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 20/09/20 alle ore 04:41:03