Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The impact of clozapine treatment on serum lipids in chronic schizophrenicpatients
Autore:
Spivak, B; Lamschtein, C; Talmon, Y; Guy, N; Mester, R; Feinberg, I; Kotler, M; Weizman, A;
Indirizzi:
Ness Ziona Psychiat Hosp, IL-74100 Ness Ziona, Israel Ness Ziona Psychiat Hosp Ness Ziona Israel IL-74100 0 Ness Ziona, Israel Tel Aviv Univ, Sackler Fac Med, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 ac Med, IL-69978 Tel Aviv, Israel Kaplan Hosp, IL-76100 Rehovot, Israel Kaplan Hosp Rehovot Israel IL-76100 aplan Hosp, IL-76100 Rehovot, Israel Ben Gurion Univ Negev, IL-84105 Beer Sheva, Israel Ben Gurion Univ Negev Beer Sheva Israel IL-84105 4105 Beer Sheva, Israel Geha Psychiat Hosp, Petah Tiqva, Israel Geha Psychiat Hosp Petah Tiqva Israel sychiat Hosp, Petah Tiqva, Israel
Titolo Testata:
CLINICAL NEUROPHARMACOLOGY
fascicolo: 2, volume: 22, anno: 1999,
pagine: 98 - 101
SICI:
0362-5664(199903/04)22:2<98:TIOCTO>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHOLESTEROL LEVELS; SUICIDALITY; AGGRESSION; REDUCTION; DISORDER; PLASMA; RISK;
Keywords:
clozapine; classical antipsychotic agents; lipids; cholesterol; triglycerides; schizophrenia;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Spivak, B Ness Ziona Psychiat Hosp, POB 1, IL-74100 Ness Ziona, Israel Ness Ziona Psychiat Hosp POB 1 Ness Ziona Israel IL-74100 srael
Citazione:
B. Spivak et al., "The impact of clozapine treatment on serum lipids in chronic schizophrenicpatients", CLIN NEUROP, 22(2), 1999, pp. 98-101

Abstract

The aim of this retrospective study is to determine whether lipid levels rise in neuroleptic-resistant chronic schizophrenic patients during clozapine treatment and if this rise is correlated with a decrease in aggressive and suicidal behavior. Seventy neuroleptic-resistant schizophrenic patients treated with clozapine for at least 6 months were compared with 30 chronic schizophrenic patients treated with classic antipsychotic agents for the same length of time. Data on serum levels of cholesterol and triglycerides andon aggressive and suicidal behavior, as measured by the Overt Aggression Scale (OAS), were collected in both groups before treatment and 6 months later. A significant reduction in aggressive and suicidal behavior was noted in the clozapine-treated group but not in the classical antipsychotic-treated group. Clozapine treatment was associated with an elevation in serum triglyceride level, whereas Classic antipsychotic treatment was associated withan increase in serum cholesterol level. We conclude that serum cholesterollevel does not play a role in the clozapine-induced attenuation in aggressive and suicidal behavior in neuroleptic-resistant schizophrenic patients, though the accompanying elevation in triglycerides may be relevant to a behavioral effect.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/06/20 alle ore 23:31:12