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Titolo:
Elevated cord serum IgE increases the risk of aeroallergen sensitization without increasing respiratory allergic symptoms in early childhood
Autore:
Tariq, SM; Arshad, SH; Matthews, SM; Hakim, EA;
Indirizzi:
St Marys Hosp, David Hide Asthma & Allergy Res Ctr, Newport PO30 5TG, Wight, England St Marys Hosp Newport Wight England PO30 5TG ort PO30 5TG, Wight, England
Titolo Testata:
CLINICAL AND EXPERIMENTAL ALLERGY
fascicolo: 8, volume: 29, anno: 1999,
pagine: 1042 - 1048
SICI:
0954-7894(199908)29:8<1042:ECSIIT>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENVIRONMENTAL-FACTORS; BIRTH COHORT; BLOOD IGE; INFANCY; PREVALENCE; ATOPY; PREDICTION; DISORDERS; CHILDREN; DISEASE;
Keywords:
asthma; atopy; cohort study; cord IgE; prediction; prevention; skin prick test;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Arshad, SH St Marys Hosp, David Hide Asthma & Allergy Res Ctr, Newport PO30 5TG, Wight, England St Marys Hosp Newport Wight England PO30 5TG G, Wight, England
Citazione:
S.M. Tariq et al., "Elevated cord serum IgE increases the risk of aeroallergen sensitization without increasing respiratory allergic symptoms in early childhood", CLIN EXP AL, 29(8), 1999, pp. 1042-1048

Abstract

Background Increasing prevalence of allergic disorders has focused attention on primary prevention. There is a need to improve the accuracy of early-life predictors of atopy so that the at-risk population can be accurately defined and preventive measures instituted. Objective The predictive capacity of elevated cord IgE, with or without family history of atopy, to allergic symptoms and skin prick test (SPT) sensitization is evaluated in a birth cohort followed up prospectively for 4 years. Methods A birth cohort of 1456 consecutively born children was recruited in 1989, Data were collected on family history of atopy and cord serum totalIgE (cord IgE) was measured. Of these, 1218 children were seen in the clinic at 4 years to determine the development of symptoms and signs of allergic disease and 981 were skin tested to a range of common food and aeroallergens. Results Of 1218 children reviewed at age 4years, 218 (17.8%) had symptoms of respiratory allergy and, of those skin tested (n = 981),192 (19.6%) reacted positively. Twice as many children with elevated cord IgE (greater thanor equal to 0.5 kU/L) at birth became sensitized to aeroallergens by age 4years (34.8% vs 17.3%, P < 0.001). Positive predictive value (PPV) of elevated cord IgE for the development of aeroallergen sensitization was better than that of family history of atopy (34.8 vs 22.6%). Combining paternal atopy with elevated cord IgE substantially increased the predictive capacity (PPV 77.8%). Cord IgE levels did not correlate with clinical asthma or rhinitis at age 4years and PPV for allergic respiratory symptoms remained poor at all cutoffs,Conclusion Cord IgE is better than family history for predicting atopy as defined by allergen sensitization and this predictive value can be further increased by combining cord IgE with paternal atopy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 03:42:31