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Titolo:
DOXEPIN AND ITS METABOLITES IN PLASMA AND CEREBROSPINAL-FLUID IN DEPRESSED-PATIENTS
Autore:
DEUSCHLE M; HARTTER S; HIEMKE C; STANDHARDT H; HEUSER I;
Indirizzi:
CENT INST MENTAL HLTH,J 5 D-68159 MANNHEIM GERMANY MAX PLANCK INST PSYCHIAT,INST CLIN D-80804 MUNICH GERMANY UNIV MAINZ,DEPT PSYCHIAT D-55131 MAINZ GERMANY
Titolo Testata:
Psychopharmacology
fascicolo: 1, volume: 131, anno: 1997,
pagine: 19 - 22
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; DESMETHYLDOXEPIN; ISOMERS;
Keywords:
DOXEPIN; CSF; PLASMA; DOXEPIN METABOLITES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
M. Deuschle et al., "DOXEPIN AND ITS METABOLITES IN PLASMA AND CEREBROSPINAL-FLUID IN DEPRESSED-PATIENTS", Psychopharmacology, 131(1), 1997, pp. 19-22

Abstract

Little information exists on the concentrations of antidepressants and their metabolites in CSF. We measured plasma and CSF levels of trans-doxepin (trans-DOX) and DOX metabolites in 12 depressed patients treated with DOX (250 mg/day) for 6 days. Spinal taps and blood samples were taken on day 7, 10h after drug administration. Trans-DOX, cis-desmethyldoxepin (cis-DM-DOX), trans-desmethyldoxepin (trans-DM-DOX) and di-desmethyldoxepin (DDM-DOX) were analyzed in CSF and plasma samples byHPLC with column-switching. Although DOX was given as a mixture of 85% trans-DOX and 15% of the pharmacologically more active cis-DOX, we found similar amounts of cis-DM-DOX and trans-DM-DOX in plasma (59.8 +/- 45.1 versus 72.0 +/- 60.0 ng/ml; NS), suggesting that isomerization of DOX had taken place. Trans-DOX and DOX metabolites could be detected in CSF of most patients. Relatively low CSF concentrations of the active metabolite cis-DM-DOX were measured. Clinical efficacy, as assessed by HAMD scores, was not significantly related to plasma or CSF concentrations of trans-DOX or its metabolites. Trans-DOX and DOX metabolites were distributed differently between plasma and CSF. It is concluded that isomerization of DOX is not only relevant for neuronal uptake inhibition, but also for the transport of the metabolites.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 21:37:32