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Titolo:
Multimodality therapy in advanced paranasal sinus carcinoma: Superior long-term results
Autore:
Lee, MH; Vokes, EE; Rosen, A; Witt, ME; Weichselbaum, RR; Haraf, DJ;
Indirizzi:
Univ Chicago Hosp, Dept Radiat & Cellular Oncol, Chicago, IL 60637 USA Univ Chicago Hosp Chicago IL USA 60637 lular Oncol, Chicago, IL 60637 USA Univ Chicago Hosp, Dept Med, Chicago, IL 60637 USA Univ Chicago Hosp Chicago IL USA 60637 p, Dept Med, Chicago, IL 60637 USA Univ Med & Dent New Jersey, Dept Otolaryngol, Newark, NJ 07103 USA Univ Med & Dent New Jersey Newark NJ USA 07103 ngol, Newark, NJ 07103 USA
Titolo Testata:
CANCER JOURNAL FROM SCIENTIFIC AMERICAN
fascicolo: 4, volume: 5, anno: 1999,
pagine: 219 - 223
SICI:
1081-4442(199907/08)5:4<219:MTIAPS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
PARA-NASAL SINUSES; LOCALLY ADVANCED HEAD; SQUAMOUS-CELL CARCINOMA; MAXILLARY SINUS; NECK-CANCER; CRANIOFACIAL RESECTION; INDUCTION CHEMOTHERAPY; RADIATION-THERAPY; TUMORS; CISPLATIN;
Keywords:
paranasal sinus cancer; multimodality therapy; long-term complication;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
32
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, MH Univ Chicago Hosp, Dept Radiat & Cellular Oncol, 5758 S Maryland Ave,MC 9006, Chicago, IL 60637 USA Univ Chicago Hosp 5758 S Maryland Ave,MC 9006 Chicago IL USA 60637
Citazione:
M.H. Lee et al., "Multimodality therapy in advanced paranasal sinus carcinoma: Superior long-term results", CA J SCI AM, 5(4), 1999, pp. 219-223

Abstract

PURPOSEThis study was conducted to determine the efficacy of multimodality treatment for stage III and IV, locoregionally advanced paranasal sinus carcinoma. PATIENTS AND METHODSA subgroup analysis of 19 consecutive patients with stage III or IV paranasal sinus carcinoma treated with multi-modality therapy from head and neck cancer protocols between 1984 and 1996 were analyzed for outcome. Sixteen patients received induction chemotherapy consisting of three cycles of cisplatin and 5-fluorouracil, followed by traditional resection (14 patients) orsurgical debulking (two patients). Surgery was followed by concomitant chemoradiotherapy with hydroxyurea and 5-fluorouracil in a week-on, week-off sequence in 15 patients. One patient received standard radiation therapy. Anadditional three patients were treated with a sequence of surgical resection followed by concomitant chemoradiotherapy, The median total dose to the primary tumor was 60 Gy (range, 45-74 Gy),RESULTSThe overall survival at 5 and 10 years by lifetable analysis was 72.7% and53.9%, respectively, and the disease-free survival at both 5 and 10 years was 66.6%, Local control was 76.1% at both 5 and 10 years. In the subgroup of patients treated with induction chemotherapy, 87% (14/16) achieved a clinical response. A complete response was confirmed at the rime of surgery infive patients, whereas 11 patients had residual disease in the surgical specimen. Regional and distant failures were unusual (one patient each), witha 10-year regional control race of 93% and a distant control rate of 95.5%. Serious, nonreversible long-term complications included two cases of unilateral blindness, one cataract, and one case of ototoxicity. DISCUSSIONAn excellent long-term outcome with respect to local control, overall survival, and disease-free survival is achieved in locoregionally advanced paranasal sinus cancer treated with induction chemotherapy, surgery and concomitant chemoradiotherapy. The 15 patients treated with this regimen had 10-year overall survival, disease-free survival, and local control rates of 56%,73%, and 79%, respectively. These results are encouraging and are superiorto the 40% survival achieved with surgery and radiation therapy Further investigation of this regimen is warranted.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:48:32