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Titolo:
Clinicopathologic study of 85 similarly treated patients with anaplastic astrocytic tumors - An analysis of DNA content (ploidy), cellular proliferation, and p53 expression
Autore:
Perry, A; Jenkins, RB; OFallon, JR; Schaefer, PL; Kimmel, DW; Mahoney, MR; Scheithauer, BW; Smith, SM; Hill, EM; Sebo, TJ; Levitt, R; Krook, J; Tschetter, LK; Morton, RF; Buckner, JC;
Indirizzi:
Mayo Clin & Mayo Fdn, Div Med Oncol, Rochester, MN 55905 USA Mayo Clin & Mayo Fdn Rochester MN USA 55905 ncol, Rochester, MN 55905 USA Washington Univ, Sch Med, St Louis, MO USA Washington Univ St Louis MO USA shington Univ, Sch Med, St Louis, MO USA Toledo Community Hosp, Oncol Program CCOP, Toledo, OH USA Toledo CommunityHosp Toledo OH USA , Oncol Program CCOP, Toledo, OH USA Meritcare Hosp CCOP, Fargo, ND USA Meritcare Hosp CCOP Fargo ND USAMeritcare Hosp CCOP, Fargo, ND USA Duluth CCOP, Duluth, MN USA Duluth CCOP Duluth MN USADuluth CCOP, Duluth, MN USA Sioux Community Canc Consortium, Sioux Falls, SD USA Sioux Community Canc Consortium Sioux Falls SD USA , Sioux Falls, SD USA Iowa Oncol Res Assoc CCOP, Des Moines, IA USA Iowa Oncol Res Assoc CCOP Des Moines IA USA soc CCOP, Des Moines, IA USA
Titolo Testata:
CANCER
fascicolo: 4, volume: 86, anno: 1999,
pagine: 672 - 683
SICI:
0008-543X(19990815)86:4<672:CSO8ST>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOW-GRADE ASTROCYTOMAS; PROGNOSTIC FACTORS; GLIOBLASTOMA-MULTIFORME; FLOW-CYTOMETRY; RADIATION-THERAPY; SUPRATENTORIAL ASTROCYTOMAS; RETROSPECTIVE ANALYSIS; SURGICAL RESECTION; LABELING INDEXES; ONCOLOGY-GROUP;
Keywords:
astrocytoma; glioma; prognosis; flow cytometry; immunohistochemistry; proliferation; Ki-67; proliferating cell nuclear antigen; p53 protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
57
Recensione:
Indirizzi per estratti:
Indirizzo: Buckner, JC Mayo Clin & Mayo Fdn, Div Med Oncol, 200 1St St Sw, Rochester,MN 55905 USA Mayo Clin & Mayo Fdn 200 1St St Sw Rochester MN USA 55905 USA
Citazione:
A. Perry et al., "Clinicopathologic study of 85 similarly treated patients with anaplastic astrocytic tumors - An analysis of DNA content (ploidy), cellular proliferation, and p53 expression", CANCER, 86(4), 1999, pp. 672-683

Abstract

BACKGROUND. The biologic behavior of anaplastic (World Health OrganizationGrade III) astrocytomas and oligoastrocytomas is highly variable, ranging from rapid progression to prolonged survival. It is difficult to predict the outcome of an individual patient based on morphology alone. METHODS. To determine the prognostic value of commonly used clinicopathologic markers, we reviewed our experience with 85 similarly treated patients enrolled in 3 North Central Cancer Treatment Group high grade glioma protocols. The pathology was comprised exclusively of primary anaplastic astrocytic tumors (66 astrocytomas and 19 oligoastrocytomas). Variables examined included patient age, morphologic type, preoperative performance score, extent of surgery, solitary versus multiple mitoses, DNA flow cytometric and image morphometric parameters, and expression of proliferating cell nuclear antigen, MIB-1, and p53 expression. RESULTS. The study was comprised of 48 men and 37 women ranging in age from 14-79 years (median age, 47 years). Overall survival ranged from <1 monthto >12 years (median, 21.6 months). Statistical analyses revealed that ageaccounted for the majority of this extensive variability in survival. The median survival rimes were 65.5 months, 22.1 months, and 4.4 months, respectively, for the groups <40 years, 40-59 years, and greater than or equal to60 years, respectively (P < 0.0001). On univariate analyses, aneuploidy byflow cytometry and a low performance score also predicted a better survival (P values of 0.04 and 0.009, respectively). Statistical trends predictinga better survival were observed for patients with a solitary mitosis and p53 immunopositivity. However, only patient age remained significant in multivariate models. CONCLUSIONS. In a small but relatively uniformly treated cohort of patients with anaplastic astrocytomas and oligoastrocytomas, patient age was associated strongly and inversely with overall survival. Once patient age was taken into account, the clinical and pathologic markers tested appeared to beof limited prognostic value. Cancer 1999;86:672-83, (C) 1999 American Cancer Society.

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Documento generato il 02/12/20 alle ore 05:39:39